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Late-onset sepsis a...
Late-onset sepsis among extremely preterm infants of 24-28 weeks gestation : an international comparison in 10 high-income countries
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- Klinger, Gil (author)
- Department of Neonatal Intensive Care, Schneider Children's Medical Center of Israel, Petah Tikva, Israel; School of Medicine, Tel Aviv University, Tel Aviv, Israel
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- Reichman, Brian (author)
- School of Medicine, Tel Aviv University, Tel Aviv, Israel; Women and Children's Health Research Unit, Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel
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- Norman, Mikael (author)
- Karolinska Institutet, Department of Clinical Science, Intervention, and Technology, Stockholm, Sweden; Department of Neonatal Medicine, Karolinska University Hospital, Stockholm, Sweden
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- Kusuda, Satoshi (author)
- Department of Pediatrics, Kyorin University, Tokyo, Japan
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- Battin, Malcolm (author)
- Newborn Service, Te Whatu Ora, Te Toka Tumai, Auckland, New Zealand
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- Helenius, Kjell (author)
- Department of Paediatrics and Adolescent Medicine, Turku University Hospital, Turku, Finland; Department of Medicine, University of Turku, Turku, Finland
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- Isayama, Tetsuya (author)
- Division of Neonatology, National Center for Child Health and Development, Tokyo, Japan
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- Lui, Kei (author)
- Department of Newborn Care, Royal Hospital for Women and School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, NSW, Sydney, Australia
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- Adams, Mark (author)
- Newborn Research, Department of Neonatology, University of Zurich, University Hospital Zurich, Zurich, Switzerland
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- Vento, Maximo (author)
- Instituto de Investigación Sanitaria (Health Research Institute) La Fe Valencia, Valencia, Spain
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- Håkansson, Stellan (author)
- Umeå universitet,Pediatrik
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- Beltempo, Marc (author)
- Department of Pediatrics, McGill University, QC, Montreal, Canada
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- Poggi, Chiara (author)
- Neonatal Intensive Care Unit, Department of Mother and Child Care, Careggi University Hospital, Florence, Italy
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- San Feliciano, Laura (author)
- Unidad de Neonatología, Hospital Universitario de Salamanca, Salamanca, Spain
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- Lehtonen, Liisa (author)
- Department of Paediatrics and Adolescent Medicine, Turku University Hospital, Turku, Finland; Department of Medicine, University of Turku, Turku, Finland
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- Bassler, Dirk (author)
- Department of Newborn Care, Royal Hospital for Women and School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, NSW, Sydney, Australia
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- Yang, Junmin (author)
- Department of Pediatrics, Mount Sinai Hospital, University of Toronto, ON, Toronto, Canada
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- Shah, Prakesh S. (author)
- Department of Pediatrics, Mount Sinai Hospital, University of Toronto, ON, Toronto, Canada
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Neonatology. - : S. Karger. - 1661-7800 .- 1661-7819.
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https://umu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- Introduction: Despite advances in neonatal care, late-onset sepsis remains an important cause of preventable morbidity and mortality. Neonatal late-onset sepsis rates have decreased in some countries, while in others they have not. Our objective was to compare trends in late-onset sepsis rates in 9 population-based networks from 10 countries and to assess the associated mortality within 7 days of late-onset sepsis.Methods: We performed a retrospective populationbased cohort study. Infants born at 24-28 weeks' gestation between 2007 and 2019 were eligible for inclusion. Lateonset sepsis was defined as a positive blood or cerebrospinal fluid culture. Late-onset sepsis rates were calculated for 3 epochs (2007-11, 2012-15, and 2016-19). Adjusted risk ratios (aRRs) for late-onset sepsis were calculated for each network.Results: Of a total of 82,850 infants, 16,914 (20.4%) had late-onset sepsis, with Japan having the lowest rate (7.1%) and Spain the highest (44.6%). Late-onset sepsis rates decreased in most networks and remained unchanged in a few. Israel, Sweden, and Finland showed the largest decrease in late-onset sepsis rates. The aRRs for late-onset sepsis showed wide variations between networks. The rate of mortality temporally related to late-onset sepsis was 10.9%. The adjusted mean length of stay for infants with late-onset sepsis was increased by 5-18 days compared to infants with no late-onset sepsis.Conclusions: One in 5 neonates of 24-28 weeks' gestation develops late-onset sepsis. Wide variability in late-onset sepsis rates exists between networks with most networks exhibiting improvement. Late-onset sepsis was associated with increased mortality and length of stay.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- Extremely preterm infants
- Late-onset sepsis
- Mortality
- Trends
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Klinger, Gil
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Reichman, Brian
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Norman, Mikael
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Kusuda, Satoshi
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Battin, Malcolm
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Helenius, Kjell
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Isayama, Tetsuya
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Lui, Kei
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Adams, Mark
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Vento, Maximo
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Håkansson, Stell ...
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Beltempo, Marc
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Poggi, Chiara
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San Feliciano, L ...
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Lehtonen, Liisa
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Bassler, Dirk
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Yang, Junmin
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Shah, Prakesh S.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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Neonatology
- By the university
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Umeå University