Long-term ambient air pollution exposure and renal function and biomarkers of renal disease

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Long-term ambient air pollution exposure and renal function and biomarkers of renal disease

Kilbo Edlund, Karl (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Univ Gothenburg, Inst Med, Sch Publ Hlth & Community Med, Sahlgrenska Acad,Occupat & Environm Med, Box 414, S-40530 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Occupat & Environm Med, Gothenburg, Sweden.

Xu, Yiyi (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Univ Gothenburg, Inst Med, Sch Publ Hlth & Community Med, Sahlgrenska Acad,Occupat & Environm Med, Box 414, S-40530 Gothenburg, Sweden.

Andersson, Eva M., 1968 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Univ Gothenburg, Inst Med, Sch Publ Hlth & Community Med, Sahlgrenska Acad,Occupat & Environm Med, Box 414, S-40530 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Occupat & Environm Med, Gothenburg, Sweden.

Christensson, Anders (author): Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Nephrol, Malmö, Sweden.

Dehlin, Mats, 1968 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Inst Med, Sahlgrenska Acad, Gothenburg, Sweden.

Forsblad d'Elia, Helena, 1961 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Inst Med, Sahlgrenska Acad, Gothenburg, Sweden.

Harari, Florencia, 1986 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Univ Gothenburg, Inst Med, Sch Publ Hlth & Community Med, Sahlgrenska Acad,Occupat & Environm Med, Box 414, S-40530 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Occupat & Environm Med, Gothenburg, Sweden.

Ljunggren, Stefan (author): Linköpings universitet,Linköping University,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Arbets- och miljömedicin,Linköping Univ, Occupat & Environm Med Ctr Linköping, Linköping, Sweden.;Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.

Molnár, Peter, 1967 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Univ Gothenburg, Inst Med, Sch Publ Hlth & Community Med, Sahlgrenska Acad,Occupat & Environm Med, Box 414, S-40530 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Occupat & Environm Med, Gothenburg, Sweden.

Oudin, Anna (author): Umeå University,Lund University,Lunds universitet,Umeå universitet,Avdelningen för hållbar hälsa,Division of Occupational and Environmental Medicine, Department of Laboratory MedicineFaculty of Medicine, Lund University, Lund, Sweden,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,CIRCLE,Institutionen för designvetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,Planetär hälsa,Forskargrupper vid Lunds universitet,LTH profilområde: Aerosoler,LTH profilområden,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH,Planetary Health,Lund University Research Groups,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH,Lund Univ, Div Occupat & Environm Med, Department Lab Med, Fac Med, Lund, Sweden.;Umeå Univ, Fac Med, Dept Publ Hlth & Clin Med, Div Sustainable Hlth, Umeå, Sweden.

Svartengren, Magnus (author): Uppsala universitet,Uppsala University,Uppsala Univ, Sweden,Arbets- och miljömedicin

Ljungman, Petter (author): Karolinska Institute,Danderyd Hospital,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Danderyd Hosp, Dept Cardiol, Stockholm, Sweden.

Stockfelt, Leo, 1981 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Univ Gothenburg, Inst Med, Sch Publ Hlth & Community Med, Sahlgrenska Acad,Occupat & Environm Med, Box 414, S-40530 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Occupat & Environm Med, Gothenburg, Sweden.

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BioMed Central (BMC), 2024
2024
English.
In: Environmental Health. - : BioMed Central (BMC). - 1476-069X. ; 23:1

Related links:: https://doi.org/10.1...; show more...; https://umu.diva-por... (primary) (Raw object); http://dx.doi.org/10... (free); https://uu.diva-port... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; https://lup.lub.lu.s...; https://urn.kb.se/re...; https://gup.ub.gu.se...; https://urn.kb.se/re...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Despite accumulating evidence of an association between air pollution and renal disease, studies on the association between long-term exposure to air pollution and renal function are still contradictory. This study aimed to investigate this association in a large population with relatively low exposure and with improved estimation of renal function as well as renal injury biomarkers.Methods: We performed a cross-sectional analysis in the middle-aged general population participating in the Swedish CardioPulmonary bioImaging Study (SCAPIS; n = 30 154). Individual 10-year exposure to total and locally emitted fine particulate matter (PM2.5), inhalable particulate matter (PM10), and nitrogen oxides (NOx) were modelled using high-resolution dispersion models. Linear regression models were used to estimate associations between exposures and estimated glomerular filtration rate (eGFR, combined creatinine and cystatin C) and serum levels of renal injury biomarkers (KIM-1, MCP-1, IL-6, IL-18, MMP-2, MMP-7, MMP-9, FGF-23, and uric acid), with consideration of potential confounders.Results: Median long-term PM2.5 exposure was 6.2 µg/m3. Almost all participants had a normal renal function and median eGFR was 99.2 mL/min/1.73 m2. PM2.5 exposure was associated with 1.3% (95% CI 0.6, 2.0) higher eGFR per 2.03 µg/m3 (interquartile range, IQR). PM2.5 exposure was also associated with elevated serum matrix metalloproteinase 2 (MMP-2) concentration, with 7.2% (95% CI 1.9, 12.8) higher MMP-2 per 2.03 µg/m3. There was a tendency towards an association between PM10 and higher levels of uric acid, but no associations were found with the other biomarkers. Associations with other air pollutants were null or inconsistent.Conclusion: In this large general population sample at low exposure levels, we found a surprising association between PM2.5 exposure and a higher renal filtration. It seems unlikely that particle function would improve renal function. However, increased filtration is an early sign of renal injury and may be related to the relatively healthy population at comparatively low exposure levels. Furthermore, PM2.5 exposure was associated with higher serum concentrations of MMP-2, an early indicator of renal and cardiovascular pathology.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)

Keyword

Air pollution
Biomarkers
eGFR
Kidney disease
Matrix metalloproteinases
Air pollution
Biomarkers
eGFR
Kidney disease
Matrix metalloproteinases

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