Search: onr:"swepub:oai:DiVA.org:umu-23397" >
Comparison of Franc...
Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains
-
Rohmer, Laurence (author)
-
Fong, Christine (author)
-
Abmayr, Simone (author)
-
show more...
-
Wasnick, Michael (author)
-
Larson Freeman, Theodore J (author)
-
Radey, Matthew (author)
-
Guina, Tina (author)
-
- Svensson, Kerstin (author)
- Umeå universitet,Infektionssjukdomar
-
Hayden, Hillary S (author)
-
Jacobs, Michael (author)
-
Gallagher, Larry A (author)
-
Manoil, Colin (author)
-
Ernst, Robert K (author)
-
Drees, Becky (author)
-
Buckley, Danielle (author)
-
Haugen, Eric (author)
-
Bovee, Donald (author)
-
Zhou, Yang (author)
-
Chang, Jean (author)
-
Levy, Ruth (author)
-
Lim, Regina (author)
-
Gillett, Will (author)
-
Guenthener, Don (author)
-
Kang, Allison (author)
-
Shaffer, Scott A (author)
-
Taylor, Greg (author)
-
Chen, Jinzhi (author)
-
Gallis, Byron (author)
-
D'Argenio, David A (author)
-
- Forsman, Mats (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
-
Olson, Maynard V (author)
-
Goodlett, David R (author)
-
Kaul, Rajinder (author)
-
Miller, Samuel I (author)
-
Brittnacher, Mitchell J (author)
-
show less...
-
(creator_code:org_t)
- BioMed Central, 2007
- 2007
- English.
-
In: Genome Biology. - : BioMed Central. - 1465-6906 .- 1474-760X. ; 8:6
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://umu.diva-por... (primary) (Raw object)
-
https://genomebiolog...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: Francisella tularensis subspecies tularensis and holarctica are pathogenic to humans, whereas the two other subspecies, novicida and mediasiatica, rarely cause disease. To uncover the factors that allow subspecies tularensis and holarctica to be pathogenic to humans, we compared their genome sequences with the genome sequence of Francisella tularensis subspecies novicida U112, which is nonpathogenic to humans. RESULTS: Comparison of the genomes of human pathogenic Francisella strains with the genome of U112 identifies genes specific to the human pathogenic strains and reveals pseudogenes that previously were unidentified. In addition, this analysis provides a coarse chronology of the evolutionary events that took place during the emergence of the human pathogenic strains. Genomic rearrangements at the level of insertion sequences (IS elements), point mutations, and small indels took place in the human pathogenic strains during and after differentiation from the nonpathogenic strain, resulting in gene inactivation. CONCLUSION: The chronology of events suggests a substantial role for genetic drift in the formation of pseudogenes in Francisella genomes. Mutations that occurred early in the evolution, however, might have been fixed in the population either because of evolutionary bottlenecks or because they were pathoadaptive (beneficial in the context of infection). Because the structure of Francisella genomes is similar to that of the genomes of other emerging or highly pathogenic bacteria, this evolutionary scenario may be shared by pathogens from other species.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Alleles
- Bacterial Typing Techniques
- Cluster Analysis
- DNA Fingerprinting
- DNA; Bacterial/analysis/chemistry/isolation & purification
- Epidemiology; Molecular/*methods
- Francisella tularensis/*classification/*genetics/isolation & purification
- Genotype
- Minisatellite Repeats
- Molecular Sequence Data
- Phylogeny
- Sequence Analysis; DNA
- Variation (Genetics)/genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Rohmer, Laurence
-
Fong, Christine
-
Abmayr, Simone
-
Wasnick, Michael
-
Larson Freeman, ...
-
Radey, Matthew
-
show more...
-
Guina, Tina
-
Svensson, Kersti ...
-
Hayden, Hillary ...
-
Jacobs, Michael
-
Gallagher, Larry ...
-
Manoil, Colin
-
Ernst, Robert K
-
Drees, Becky
-
Buckley, Daniell ...
-
Haugen, Eric
-
Bovee, Donald
-
Zhou, Yang
-
Chang, Jean
-
Levy, Ruth
-
Lim, Regina
-
Gillett, Will
-
Guenthener, Don
-
Kang, Allison
-
Shaffer, Scott A
-
Taylor, Greg
-
Chen, Jinzhi
-
Gallis, Byron
-
D'Argenio, David ...
-
Forsman, Mats
-
Olson, Maynard V
-
Goodlett, David ...
-
Kaul, Rajinder
-
Miller, Samuel I
-
Brittnacher, Mit ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Microbiology in ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Infectious Medic ...
- Articles in the publication
-
Genome Biology
- By the university
-
Umeå University