Search: onr:"swepub:oai:DiVA.org:umu-24835" >
Detection of vitami...
Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin.
- Article/chapterEnglish2007
Publisher, publication year, extent ...
-
2007-05-01
-
Oxford University Press (OUP),2007
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:umu-24835
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-24835URI
-
https://doi.org/10.1373/clinchem.2006.080382DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
BACKGROUND: Impaired vitamin B(12) function and decreased vitamin B(12) status have been associated with neurological and cognitive impairment. Current assays analyze total vitamin B(12) concentration, only a small percentage of which is metabolically active. Concentrations of this active component, carried on holotranscobalamin (holoTC), may be of greater relevance than total vitamin B(12). METHODS: We compared the utility of serum holoTC with conventional vitamin B(12) for detection of vitamin B(12) deficiency in a population-based study of older people, using increased methylmalonic acid (MMA) concentrations as a marker of metabolic vitamin B(12) deficiency in the overall population (n = 2403) and in subsets with normal (n = 1651) and abnormal (n = 752) renal function. RESULTS: Among all participants, 6% had definite (MMA >0.75 micromol/L) and 16% had probable (MMA >0.45 micromol/L) metabolic vitamin B(12) deficiency. In receiver operating characteristic curves for detection of definite vitamin B(12) deficiency, holoTC had a greater area under the curve (AUC) compared with vitamin B(12) in all participants (0.85 vs 0.76; P <0.001) and in subsets with normal (AUC: 0.87 vs 0.79; P <0.001) and abnormal (AUC: 0.85 vs 0.74; P = 0.002) renal function. Similar findings were observed for detection of moderate vitamin B(12) deficiency. Whereas the positive predictive value for both holoTC and vitamin B(12) was greater for detection of probable than definite vitamin B(12) deficiency, both tests were associated with more false-positive than true-positive test results. CONCLUSIONS: HoloTC has a modestly superior diagnostic accuracy compared with conventional vitamin B(12) for the detection of vitamin B(12) deficiency, but neither test can be recommended to screen asymptomatic populations.
Added entries (persons, corporate bodies, meetings, titles ...)
-
Sherliker, Paul
(author)
-
Hin, Harold
(author)
-
Nexo, Ebba
(author)
-
Hvas, Anne Mette
(author)
-
Schneede, JoernUmeå universitet,Klinisk kemi
(author)
-
Birks, Jacqueline
(author)
-
Ueland, Per M
(author)
-
Emmens, Kathleen
(author)
-
Scott, John M
(author)
-
Molloy, Anne M
(author)
-
Evans, John Grimley
(author)
-
Umeå universitetKlinisk kemi
(creator_code:org_t)
Related titles
-
In:Clinical Chemistry: Oxford University Press (OUP)53:5, s. 963-9700009-91471530-8561
Internet link
Find in a library
To the university's database
- By the author/editor
-
Clarke, Robert
-
Sherliker, Paul
-
Hin, Harold
-
Nexo, Ebba
-
Hvas, Anne Mette
-
Schneede, Joern
-
show more...
-
Birks, Jacquelin ...
-
Ueland, Per M
-
Emmens, Kathleen
-
Scott, John M
-
Molloy, Anne M
-
Evans, John Grim ...
-
show less...
- Articles in the publication
-
Clinical Chemist ...
- By the university
-
Umeå University