Metabolomic patterns in glioblastoma and changes during radiotherapy: a clinical microdialysis study

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Wibom, Carl,1977-Umeå universitet,Onkologi (author)

Metabolomic patterns in glioblastoma and changes during radiotherapy : a clinical microdialysis study

Article/chapterEnglish2010

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2010-04-22
American Chemical Society (ACS),2010
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LIBRIS-ID:oai:DiVA.org:umu-25668
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25668URI
https://doi.org/10.1021/pr901088rDOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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We employed stereotactic microdialysis to sample extracellular fluid intracranially from glioblastoma patients, before and during the first five days of conventional radiotherapy treatment. Microdialysis catheters were implanted in the contrast enhancing tumor as well as in the brain adjacent to tumor (BAT). Reference samples were collected subcutaneously from the patients' abdomen. The samples were analyzed by gas chromatography-time-of-flight mass spectrometry (GC-TOF MS), and the acquired data was processed by hierarchical multivariate curve resolution (H-MCR) and analyzed with orthogonal partial least-squares (OPLS). To enable detection of treatment-induced alterations, the data was processed by individual treatment over time (ITOT) normalization. One-hundred fifty-one metabolites were reliably detected, of which 67 were identified. We found distinct metabolic differences between the intracranially collected samples from tumor and the BAT region. There was also a marked difference between the intracranially and the subcutaneously collected samples. Furthermore, we observed systematic metabolic changes induced by radiotherapy treatment among both tumor and BAT samples. The metabolite patterns affected by treatment were different between tumor and BAT, both containing highly discriminating information, ROC values of 0.896 and 0.821, respectively. Our findings contribute to increased molecular knowledge of basic glioblastoma pathophysiology and point to the possibility of detecting metabolic marker patterns associated to early treatment response.

Subject headings and genre

NATURVETENSKAP Kemi hsv//swe
NATURAL SCIENCES Chemical Sciences hsv//eng
chemometrics
gas chromatography-mass spectrometry
glioblastoma
metabolomics
predictive metabolomics
radiotherapy
treatment response

Added entries (persons, corporate bodies, meetings, titles ...)

Surowiec, Izabella,1978-Umeå universitet,Kemiska institutionen(Swepub:umu)izsu0001 (author)
Mörén, Lina,1985-Umeå universitet,Kemiska institutionen(Swepub:umu)liamen04 (author)
Bergström, PerUmeå universitet,Onkologi(Swepub:umu)pebe0049 (author)
Johansson, MikaelUmeå universitet,Onkologi(Swepub:umu)mijo0025 (author)
Antti, Henrik,1970-Umeå universitet,Kemiska institutionen(Swepub:umu)hean0004 (author)
Bergenheim, A TommyUmeå universitet,Klinisk neurovetenskap(Swepub:umu)tobe0004 (author)
Umeå universitetOnkologi (creator_code:org_t)

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In:Journal of Proteome Research: American Chemical Society (ACS)9:6, s. 2909-29191535-38931535-3907

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