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PDK1 signaling in o...
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Dubbaka Venu, Pradeep Reddy,1982-Umeå universitet,Institutionen för medicinsk kemi och biofysik
(author)
PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2009-05-07
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Oxford University Press (OUP),2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-26086
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-26086URI
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https://doi.org/10.1093/hmg/ddp217DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:119047296URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The molecular mechanisms that control reproductive aging and menopausal age in females are poorly understood. Here, we provide genetic evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) signaling in oocytes preserves reproductive lifespan by maintaining the survival of ovarian primordial follicles. In mice lacking the PDK1-encoding gene Pdk1 in oocytes, the majority of primordial follicles are depleted around the onset of sexual maturity, causing premature ovarian failure (POF) during early adulthood. We further showed that suppressed PDK1-Akt-p70 S6 kinase 1 (S6K1)-ribosomal protein S6 (rpS6) signaling in oocytes appears to be responsible for the loss of primordial follicles, and mice lacking the Rps6 gene in oocytes show POF similar to that in Pdk1-deficient mice. In combination with our earlier finding that phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in oocytes suppresses follicular activation, we have now pinpointed the molecular network involving phosphatidylinositol 3 kinase (PI3K)/PTEN-PDK1 signaling in oocytes that controls the survival, loss and activation of primordial follicles, which together determine reproductive aging and the length of reproductive life in females. Underactivation or overactivation of this signaling pathway in oocytes is shown to cause pathological conditions in the ovary, including POF and infertility.
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Adhikari, DeepakUmeå universitet,Institutionen för medicinsk kemi och biofysik(Swepub:umu)dead0002
(author)
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Zheng, WenjingUmeå universitet,Institutionen för medicinsk kemi och biofysik(Swepub:umu)wezh0004
(author)
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Liang, Shawn
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Hämäläinen, Tuula
(author)
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Tohonen, Virpi
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Ogawa, Wataru
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Noda, Tetsuo
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Volarevic, Sinisa
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Huhtaniemi, Ilpo
(author)
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Liu, KuiUmeå universitet,Institutionen för medicinsk kemi och biofysik(Swepub:umu)kuli0001
(author)
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Umeå universitetInstitutionen för medicinsk kemi och biofysik
(creator_code:org_t)
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In:Human Molecular Genetics: Oxford University Press (OUP)18:15, s. 2813-28240964-69061460-2083
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Dubbaka Venu, Pr ...
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Adhikari, Deepak
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Zheng, Wenjing
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Liang, Shawn
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Hämäläinen, Tuul ...
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Tohonen, Virpi
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Ogawa, Wataru
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Noda, Tetsuo
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Volarevic, Sinis ...
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Huhtaniemi, Ilpo
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Liu, Kui
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Human Molecular ...
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Umeå University
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Karolinska Institutet