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Quantitative trait ...
Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3).
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2009-07-02
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Oxford University Press (OUP),2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-26425
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-26425URI
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https://doi.org/10.1093/hmg/ddp302DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Twin studies suggest a heritable component to circulating sex steroid hormones and sex hormone-binding globulin (SHBG). In the NCI-Breast and Prostate Cancer Cohort Consortium, 874 SNPs in 37 candidate genes in the sex steroid hormone pathway were examined in relation to circulating levels of SHBG (N = 4720), testosterone (N = 4678), 3 alpha-androstanediol-glucuronide (N = 4767) and 17beta-estradiol (N = 2014) in Caucasian men. rs1799941 in SHBG is highly significantly associated with circulating levels of SHBG (P = 4.52 x 10(-21)), consistent with previous studies, and testosterone (P = 7.54 x 10(-15)), with mean difference of 26.9 and 14.3%, respectively, comparing wild-type to homozygous variant carriers. Further noteworthy novel findings were observed between SNPs in ESR1 with testosterone levels (rs722208, mean difference = 8.8%, P = 7.37 x 10(-6)) and SRD5A2 with 3 alpha-androstanediol-glucuronide (rs2208532, mean difference = 11.8%, P = 1.82 x 10(-6)). Genetic variation in genes in the sex steroid hormone pathway is associated with differences in circulating SHBG and sex steroid hormones.
Added entries (persons, corporate bodies, meetings, titles ...)
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Schumacher, Fredrick R
(author)
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Berndt, Sonja I
(author)
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Pfeiffer, Ruth
(author)
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Albanes, Demetrius
(author)
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Andriole, Gerald L
(author)
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Ardanaz, Eva
(author)
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Boeing, Heiner
(author)
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Bueno-de-Mesquita, Bas
(author)
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Chanock, Stephen J
(author)
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Clavel-Chapelon, Françoise
(author)
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Diver, W Ryan
(author)
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Feigelson, Heather Spencer
(author)
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Gaziano, J Michael
(author)
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Giovannucci, Edward
(author)
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Haiman, Christopher A
(author)
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Henderson, Brian E
(author)
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Hoover, Robert N
(author)
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Kolonel, Laurence N
(author)
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Kraft, Peter
(author)
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Ma, Jing
(author)
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Le Marchand, Loïc
(author)
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Overvad, Kim
(author)
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Palli, Domenico
(author)
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Stattin, PärUmeå universitet,Urologi och andrologi(Swepub:umu)past0003
(author)
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Stampfer, Meir
(author)
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Stram, Daniel O
(author)
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Thomas, Gilles
(author)
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Thun, Michael J
(author)
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Travis, Ruth C
(author)
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Trichopoulos, Dimitrios
(author)
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Virtamo, Jarmo
(author)
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Weinstein, Stephanie J
(author)
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Yeager, Meredith
(author)
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Kaaks, Rudolf
(author)
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Hunter, David J
(author)
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Hayes, Richard B
(author)
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Umeå universitetUrologi och andrologi
(creator_code:org_t)
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In:Human molecular genetics: Oxford University Press (OUP)18:19, s. 3749-571460-20830964-6906
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Ahn, Jiyoung
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Schumacher, Fred ...
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Berndt, Sonja I
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Pfeiffer, Ruth
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Albanes, Demetri ...
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Andriole, Gerald ...
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Ardanaz, Eva
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Boeing, Heiner
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Bueno-de-Mesquit ...
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Chanock, Stephen ...
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Clavel-Chapelon, ...
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Diver, W Ryan
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Feigelson, Heath ...
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Gaziano, J Micha ...
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Giovannucci, Edw ...
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Haiman, Christop ...
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Henderson, Brian ...
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Hoover, Robert N
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Kolonel, Laurenc ...
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Kraft, Peter
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Ma, Jing
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Le Marchand, Loï ...
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Overvad, Kim
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Palli, Domenico
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Stattin, Pär
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Stampfer, Meir
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Stram, Daniel O
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Thomas, Gilles
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Thun, Michael J
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Travis, Ruth C
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Trichopoulos, Di ...
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Virtamo, Jarmo
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Weinstein, Steph ...
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Yeager, Meredith
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Kaaks, Rudolf
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Hunter, David J
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Hayes, Richard B
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Umeå University