Dopamine D(1) receptors and age differences in brain activation during working memory

Bäckman, Lars (author): Stockholms universitet,Karolinska Institutet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)

Karlsson, Sari (author): Stockholms universitet,Karolinska Institutet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)

Fischer, Håkan (author): Stockholms universitet,Karolinska Institutet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Psykologiska institutionen

Brehmer, Yvonne (author): Stockholms universitet,Karolinska Institutet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)

Rieckmann, Anna (author): Stockholms universitet,Karolinska Institutet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)

Macdonald, Stuart WS (author): Aging Research Center, Karolinska Institutet, Gävlegatan 16, SE-113 30 Stockholm, Sweden; Department of Psychology, University of Victoria, Canada

Nyberg, Lars (author): Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för strålningsvetenskaper,Institutionen för integrativ medicinsk biologi (IMB)

(creator_code:org_t)

Fayetteville, N.Y : Elsevier, 2011
2011
English.
In: Neurobiology of Aging. - Fayetteville, N.Y : Elsevier. - 0197-4580 .- 1558-1497. ; 32:10, s. 1849-1856

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Abstract Subject headings

In an fMRI study, 20 younger and 20 healthy older adults were scanned while performing a spatial working-memory task under two levels of load. On a separate occasion, the same subjects underwent PET measurements using the radioligand [(11)C] SCH23390 to determine dopamine D(1) receptor binding potential (BP) in caudate nucleus and dorsolateral prefrontal cortex (DLPFC). The fMRI study revealed a significant load modulation of brain activity (higher load>lower load) in frontal and parietal regions for younger, but not older, adults. The PET measurements showed marked age-related reductions of D(1) BP in caudate and DLPFC. Statistical control of caudate and DLPFC D(1) binding eliminated the age-related reduction in load-dependent BOLD signal in left frontal cortex, and attenuated greatly the reduction in right frontal and left parietal cortex. These findings suggest that age-related alterations in dopaminergic neurotransmission may contribute to underrecruitment of task-relevant brain regions during working-memory performance in old age.

By the author/editor: Bäckman, Lars; Karlsson, Sari; Fischer, Håkan; Karlsson, Per; Brehmer, Yvonne; Rieckmann, Anna; show more...; Macdonald, Stuar ...; Farde, Lars; Nyberg, Lars; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

By the university: Umeå University; Karolinska Institutet; Stockholm University

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