onr:"swepub:oai:DiVA.org:umu-31991"
Search: onr:"swepub:oai:DiVA.org:umu-31991" > Age-related differe...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Burzynska, A ZMax Planck Institute for Human Development, Berlin (author)
Age-related differences in white matter microstructure : region-specific patterns of diffusivity.
- Article/chapterEnglish2010
Publisher, publication year, extent ...
- San Diego ; Orlando, Fla :Elsevier BV,2010
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-31991
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-31991URI
- https://doi.org/10.1016/j.neuroimage.2009.09.041DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-84273URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:119902183URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- We collected MRI diffusion tensor imaging data from 80 younger (20-32 years) and 63 older (60-71 years) healthy adults. Tract-based spatial statistics (TBSS) analysis revealed that white matter integrity, as indicated by decreased fractional anisotropy (FA), was disrupted in numerous structures in older compared to younger adults. These regions displayed five distinct region-specific patterns of age-related differences in other diffusivity properties: (1) increases in both radial and mean diffusivity; (2) increases in radial diffusivity; (3) no differences in parameters other than FA; (4) a decrease in axial and an increase in radial diffusivity; and (5) a decrease in axial and mean diffusivity. These patterns suggest different biological underpinnings of age-related decline in FA, such as demyelination, Wallerian degeneration, gliosis, and severe fiber loss, and may represent stages in a cascade of age-related degeneration in white matter microstructure. This first simultaneous description of age-related differences in FA, mean, axial, and radial diffusivity requires histological and functional validation as well as analyses of intermediate age groups and longitudinal samples.
Subject headings and genre
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Preuschhof, CMax Planck Institute for Human Development, Berlin (author)
- Bäckman, LKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Max Planck Institute for Human Development, Berlin, Karolinska Institute (author)
- Nyberg, LarsUmeå universitet,Fysiologi,Diagnostisk radiologi,Department of Radiation Sciences (Diagnostic Radiology) and Integrative Medical Biology (Physiology Section), Umeå University,(Swepub:umu)lany0001 (author)
- Li, S-CMax Planck Institute for Human Development, Berlin (author)
- Lindenberger, UMax Planck Institute for Human Development, Berlin, (author)
- Heekeren, H RMax Planck Institute for Human Development, Berlin, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig (author)
- Max Planck Institute for Human Development, BerlinCentrum för forskning om äldre och åldrande (ARC), (tills m KI) (creator_code:org_t)
Related titles
- In:NeuroImageSan Diego ; Orlando, Fla : Elsevier BV49:3, s. 2104-21121053-81191095-9572
Internet link
- https://pure.mpg.de/pubman/item/item_2099336_6/component/file_2099335/ABU_Age_2010.pdf
- http://library.mpib-berlin.mpg.de/ft/abu/ABU_Age_2010.pdf ; http://www.sciencedirect.com/science/article/pii/S1053811909010209
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-31991
- https://doi.org/10.1016/j.neuroimage.2009.09.041
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-84273
- http://kipublications.ki.se/Default.aspx?queryparsed=id:119902183
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Burzynska, A Z
- Preuschhof, C
- Bäckman, L
- Nyberg, Lars
- Li, S-C
- Lindenberger, U
- show more...
- Heekeren, H R
- show less...
- Articles in the publication
- NeuroImage
- By the university
- Umeå University
- Stockholm University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
