Search: onr:"swepub:oai:DiVA.org:umu-31995" > Modulation of stria...
Fältnamn | Indikatorer | Metadata |
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000 | 04081naa a2200649 4500 | |
001 | oai:DiVA.org:umu-31995 | |
003 | SwePub | |
008 | 100226s2009 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:120065373 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-319952 URI |
024 | 7 | a https://doi.org/10.1016/j.neuroimage.2009.06.0302 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1200653732 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Karlsson, Sariu Karolinska Institutet4 aut |
245 | 1 0 | a Modulation of striatal dopamine D1 binding by cognitive processing |
264 | 1 | b Elsevier,c 2009 |
338 | a print2 rdacarrier | |
520 | a There is strong evidence that dopamine (DA) is implicated in higher-order cognitive functioning, but it remains controversial whether D1 receptor binding can be modified by cognitive activity. We examined striatal D1 binding potential (BP) in 20 younger (22-30 years) and 20 older (65-75 years) persons who underwent two [(11)C] SCH 23390 PET measurements, one while resting and one while performing a cognitive task taxing inhibitory functioning. The younger persons showed significant task-related BP reductions in sensorimotor, limbic, and associative striatum during cognitive activity compared to rest. Older persons showed no reliable BP reductions in any striatal subregion. These findings demonstrate that D1 receptor binding can be modified by cognitive activity in younger persons, but also provide novel evidence for the notion that human aging is associated not only with lower DA receptor density but also with altered modifiability of the DA system. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
650 | 7 | a SAMHÄLLSVETENSKAPx Psykologi0 (SwePub)5012 hsv//swe |
650 | 7 | a SOCIAL SCIENCESx Psychology0 (SwePub)5012 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
653 | a Dopamine release | |
653 | a D1 binding | |
653 | a SCH 23390 | |
653 | a Striatum | |
653 | a Aging | |
653 | a Cognition | |
653 | a Physiology | |
653 | a Fysiologi | |
653 | a Neurology | |
653 | a Neurologi | |
653 | a Psychiatry | |
653 | a Psykiatri | |
700 | 1 | a Nyberg, Larsu Umeå universitet,Diagnostisk radiologi,Fysiologi4 aut0 (Swepub:umu)lany0001 |
700 | 1 | a Karlsson, Peru Karolinska Institutet4 aut |
700 | 1 | a Fischer, Håkanu Karolinska Institutet4 aut |
700 | 1 | a Thilers, Petrau Aging Research Center, Karolinska Institutet, Stockholm, Sweden4 aut |
700 | 1 | a MacDonald, Stuartu Aging Research Center, Karolinska Institutet, Stockholm, Sweden,Department of Psychology, University of Victoria, Victoria BC, Canada4 aut |
700 | 1 | a Brehmer, Yvonneu Karolinska Institutet4 aut |
700 | 1 | a Rieckmann, Annau Karolinska Institutet4 aut0 (Swepub:umu)anri0051 |
700 | 1 | a Halldin, Christeru Karolinska Institutet4 aut |
700 | 1 | a Farde, Larsu Karolinska Institutet4 aut |
700 | 1 | a Bäckman, Larsu Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Diagnostisk radiologi4 org |
773 | 0 | t NeuroImaged : Elsevierg 48:2, s. 398-404q 48:2<398-404x 1053-8119x 1095-9572 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-31995 |
856 | 4 8 | u https://doi.org/10.1016/j.neuroimage.2009.06.030 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:120065373 |
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