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- MacDonald, Stuart W SUniv Victoria, Dept Psychol, Victoria, BC V8W 3P5, Canada.;Karolinska Inst, Aging Res Ctr, S-11330 Stockholm, Sweden. (author)
Extrastriatal dopamine D2 receptor binding modulates intraindividual variability in episodic recognition and executive functioning.
- Article/chapterEnglish2009
Publisher, publication year, extent ...
- Elsevier BV,2009
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-31996
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-31996URI
- https://doi.org/10.1016/j.neuropsychologia.2009.01.016DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440754URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:119062103URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Intraindividual variability (IIV) reflects lawful but transient within-person changes in performance. Increased IIV in cognition shares systematic associations with numerous conditions characterized by alterations in dopamine (DA) neuromodulation (e.g., old age, ADHD, schizophrenia, and Parkinson's disease). In a group of normal middle-aged adults, we examined links between PET-derived measures of D2 receptor binding in striatum, orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and hippocampus (HC) and IIV for tasks assessing recognition memory and executive functioning. An index of IIV, the intraindividual standard deviation (ISD), was computed across successful response latency trials for each cognitive outcome. Lower D2 binding in OC, ACC, and HC, but not striatum, was associated with increasing ISDs for the memory and executive measures. Consistent with neurocomputational models, the present findings suggest a role for extrastriatal DA neurotransmission in modulating variability in cognitive functioning.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
- PET
- Intraindividual variability
- Dopamine
- Executive functioning
- Recognition memory
- MEDICINE
- MEDICIN
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- Cervenka, SimonKarolinska Institutet(Swepub:uu)simce160 (author)
- Farde, LarsKarolinska Institutet (author)
- Nyberg, LarsUmeå universitet,Fysiologi,Diagnostisk radiologi,Umea Univ, Dept Radiat Sci Diagnost Radiol, S-90187 Umea, Sweden.;Umea Univ, Dept Integrat Med Biol Physiol, S-90187 Umea, Sweden.(Swepub:umu)lany0001 (author)
- Bäckman, LarsKarolinska Institutet (author)
- Karolinska InstitutetUniv Victoria, Dept Psychol, Victoria, BC V8W 3P5, Canada.;Karolinska Inst, Aging Res Ctr, S-11330 Stockholm, Sweden. (creator_code:org_t)
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- In:Neuropsychologia: Elsevier BV47:11, s. 2299-23040028-39321873-3514
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