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- Åström, Stefan UUmeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet) (author)
Rit1, a tRNA backbone-modifying enzyme that mediates initiator and elongator tRNA discrimination
- Article/chapterEnglish1994
Publisher, publication year, extent ...
- Elsevier,1994
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:umu-32181
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-32181URI
- https://doi.org/10.1016/0092-8674(94)90262-3DOI
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- Language:English
- Summary in:English
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Notes
- Using a genetic screen in yeast aimed at identifying cellular factors involved in initiator and elongator methionine tRNA discrimination in the translational process, we have identified a mutation that abolish the requirement for elongator methionine tRNA. The gene affected, which we call the ribosylation of the initiator tRNA gene or RIT1, encodes a 2'-O-ribosyl phosphate transferase. This enzyme modifies exclusively the initiator tRNA in position 64 using 5'-phosphoribosyl-1'-pyrophosphate as the modification donor. As the initiator tRNA participates both in the initiation and elongation of translation in a rit1 strain, we conclude that the 2'-O-ribosyl phosphate modification discriminates the initiator tRNAs from the elongator tRNAs during protein synthesis. The modification enzyme was shown to recognize the stem-loop IV region that is unique in eukaryotic cytoplasmic initiator tRNAs.
Subject headings and genre
- NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
- Cell and molecular biology
- Cell- och molekylärbiologi
- Molecular biology
- Molekylärbiologi
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- Byström, Anders SUmeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)(Swepub:umu)anby0001 (author)
- Umeå universitetInstitutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet) (creator_code:org_t)
Related titles
- In:Cell: Elsevier79:3, s. 535-5460092-86741097-4172
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