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Macrophage inhibito...
Macrophage inhibitory cytokine 1 : a new prognostic marker in prostate cancer.
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- Brown, David A (author)
- St Vincents Hosp, Ctr Appl Med Res, Sydney, NSW 2010, Australia.;Univ New S Wales, Sydney, NSW, Australia.
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- Lindmark, Fredrik (author)
- Umeå universitet,Institutionen för strålningsvetenskaper,Umea Univ, Dept Radiat Sci, Umea, Sweden.
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- Stattin, Pär (author)
- Umeå universitet,Urologi och andrologi,Umea Univ, Dept Surg & Preoperat Sci, Umea, Sweden.
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- Bälter, Katarina (author)
- Karolinska Institutet
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- Adami, Hans-Olov (author)
- Karolinska Institutet
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- Zheng, Sigun L (author)
- Wake Forest Univ, Ctr Human Genom, Winston Salem, NC 27109 USA.
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- Xu, Jianfeng (author)
- Wake Forest Univ, Ctr Human Genom, Winston Salem, NC 27109 USA.
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- Isaacs, William B (author)
- Johns Hopkins Univ, Dept Urol, Baltimore, MD USA.
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- Grönberg, Henrik (author)
- Karolinska Institutet
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- Breit, Samuel N (author)
- St Vincents Hosp, Ctr Appl Med Res, Sydney, NSW 2010, Australia.;Univ New S Wales, Sydney, NSW, Australia.
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- Wiklund, Fredrik E (author)
- Karolinska Institutet
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St Vincents Hosp, Ctr Appl Med Res, Sydney, NSW 2010, Australia;Univ New S Wales, Sydney, NSW, Australia. Institutionen för strålningsvetenskaper (creator_code:org_t)
- AMER ASSOC CANCER RESEARCH, 2009
- 2009
- English.
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In: Clinical Cancer Research. - : AMER ASSOC CANCER RESEARCH. - 1078-0432 .- 1557-3265. ; 15:21, s. 6658-6664
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- PURPOSE: High serum levels of macrophage inhibitory cytokine 1 (MIC-1) are strongly associated with metastatic prostate cancer, suggesting MIC-1 is a biomarker for prostate cancer prognosis. EXPERIMENTAL DESIGN: We conducted a prospective cohort study of 1,442 Swedish men with a pathologically verified diagnosis of prostate cancer between 2001 and 2003. Blood was drawn either pretreatment (n = 431) or posttreatment (n = 1,011) and cases were followed for a mean time of 4.9 years (range, 0.1-6.8 years). RESULTS: MIC-1 serum levels independently predicted poor cancer-specific survival with an almost 3-fold higher cancer death rate in patients with serum levels in the highest quartile compared with men with serum levels in the lowest quartile (adjusted hazard ratio, 2.98; 95% confidence interval, 1.82-4.68). Pretreatment MIC-1 levels revealed an even stronger association with disease outcome with an 8-fold higher death rate in the highest compared with the lowest category (adjusted hazard ratio, 7.98; 95% confidence interval, 1.73-36.86). Among patients considered to have localized disease, MIC-1 significantly increased the discriminative capacity between indolent and lethal prostate cancer compared with the established prognostic markers clinical stage, pathologic grade, and prostate-specific antigen level (P = 0.016). A sequence variant in the MIC-1 gene was associated with decreased MIC-1 serum levels (P = 0.002) and decreased prostate cancer mortality (P = 0.003), suggesting a causative role of MIC-1 in prostate cancer prognosis. CONCLUSIONS: Serum MIC-1 concentration is a novel biomarker capable of predicting prostate cancer prognosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Brown, David A
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Lindmark, Fredri ...
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Stattin, Pär
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Bälter, Katarina
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Adami, Hans-Olov
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Zheng, Sigun L
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show more...
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Xu, Jianfeng
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Isaacs, William ...
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Grönberg, Henrik
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Breit, Samuel N
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Wiklund, Fredrik ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
- Articles in the publication
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Clinical Cancer ...
- By the university
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Umeå University
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Mälardalen University
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Karolinska Institutet