Search: onr:"swepub:oai:DiVA.org:umu-32832" >
Glutamate NMDAR1 re...
Glutamate NMDAR1 receptors localised to nerves in human Achilles tendons. Implications for treatment?
-
- Alfredson, Håkan (author)
- Umeå universitet,Idrottsmedicin
-
- Forsgren, Sture (author)
- Umeå universitet,Anatomi
-
- Thorsen, Kim (author)
- Umeå universitet,Idrottsmedicin
-
show more...
-
- Fahlström, Martin (author)
- Umeå universitet,Rehabiliteringsmedicin,Idrottsmedicin
-
Johansson, Håkan (author)
-
- Lorentzon, Ronny (author)
- Umeå universitet,Idrottsmedicin
-
show less...
-
(creator_code:org_t)
- 2001-02-16
- 2001
- English.
-
In: Knee Surgery, Sports Traumatology, Arthroscopy. - : Springer Science and Business Media LLC. - 0942-2056 .- 1433-7347. ; 9:2, s. 123-126
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- In this investigation, we show the presence of both free glutamate (microdialysis) and glutamate NMDAR1 receptors (immunohistochemical analyses of tendon biopsies), in tendons from patients with chronic Achilles tendon pain (Achilles tendinosis) and in controls (pain-free tendons). The NMDAR1 immunoreaction was usually confined to acetylcholinesterase-positive structures, implying that the reaction is present in nerves. Glutamate is a potent pain mediator in the human central nervous system, and in animals it has been shown that peripherally administered glutamate NMDA receptor antagonists diminish the response to formalin-induced nociception. Our present finding of glutamate NMDA receptors in human Achilles tendons might have implications for pain treatment.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database