The Listeria transcriptional landscape from saprophytism to virulence

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The Listeria transcriptional landscape from saprophytism to virulence

Toledo-Arana, Alejandro (author)

Dussurget, Olivier (author)

Nikitas, Georgios (author)

Sesto, Nina (author)

Guet-Revillet, Hélène (author)

Balestrino, Damien (author)

Loh, Edmund, 1981- (author): Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten),Johansson J

Gripenland, Jonas (author): Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Umeå Centre for Microbial Research (UCMR),jonas.gripenland@molbiol.umu.se

Tiensuu, Teresa (author): Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Umeå Centre for Microbial Research (UCMR),Molekylär Infektionsmedicin, Sverige (MIMS),Johansson J

Vaitkevicius, Karolis (author): Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Umeå Centre for Microbial Research (UCMR),Johansson J

Barthelemy, Mathieu (author)

Vergassola, Massimo (author)

Nahori, Marie-Anne (author)

Soubigou, Guillaume (author)

Régnault, Béatrice (author)

Coppée, Jean-Yves (author)

Lecuit, Marc (author)

Johansson, Jörgen (author): Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Umeå Centre for Microbial Research (UCMR),Johansson J

Cossart, Pascale (author)

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(creator_code:org_t)

2009-05-17
2009
English.
In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 459:7249, s. 950-956

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

The bacterium Listeria monocytogenes is ubiquitous in the environment and can lead to severe food-borne infections. It has recently emerged as a multifaceted model in pathogenesis. However, how this bacterium switches from a saprophyte to a pathogen is largely unknown. Here, using tiling arrays and RNAs from wild-type and mutant bacteria grown in vitro, ex vivo and in vivo, we have analysed the transcription of its entire genome. We provide the complete Listeria operon map and have uncovered far more diverse types of RNAs than expected: in addition to 50 small RNAs (<500 nucleotides), at least two of which are involved in virulence in mice, we have identified antisense RNAs covering several open-reading frames and long overlapping 5' and 3' untranslated regions. We discovered that riboswitches can act as terminators for upstream genes. When Listeria reaches the host intestinal lumen, an extensive transcriptional reshaping occurs with a SigB-mediated activation of virulence genes. In contrast, in the blood, PrfA controls transcription of virulence genes. Remarkably, several non-coding RNAs absent in the non-pathogenic species Listeria innocua exhibit the same expression patterns as the virulence genes. Together, our data unravel successive and coordinated global transcriptional changes during infection and point to previously unknown regulatory mechanisms in bacteria.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

Keyword

11-beta-Hydroxysteroid Dehydrogenase Type 1/*genetics/metabolism
Animals
Cerebral Cortex/enzymology/metabolism
Circadian Rhythm
Corticosterone/blood
Gene Expression Regulation; Enzymologic
Hippocampus/enzymology/*metabolism
Male
Obesity/blood/enzymology/*genetics
RNA; Messenger/metabolism
Rats
Rats; Sprague-Dawley
Rats; Zucker
MEDICINE
MEDICIN

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Microbiology in ...

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By the university: Umeå University

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