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- Gustafsson, AnnaMalmö högskola,Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,Fakulteten för hälsa och samhälle (HS) (author)
Gas6 and the receptor tyrosine kinase Axl in clear cell renal cell carcinoma.
- Article/chapterEnglish2009
Publisher, publication year, extent ...
- 2009-10-30
- Public Library of Science (PLoS),2009
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-33260
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-33260URI
- https://doi.org/10.1371/journal.pone.0007575DOI
- https://lup.lub.lu.se/record/1512262URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-4091URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- BACKGROUND: The molecular biology of renal cell carcinoma (RCC) is complex and not fully understood. We have recently found that the expression of the receptor tyrosine kinase Axl in the RCC tumors independently correlates with survival of the patients. PRINCIPAL FINDINGS: Here, we have investigated the role of Axl and its ligand Gas6, the vitamin-K dependent protein product of the growth arrest-specific gene 6, in clear cell RCC (ccRCC) derived cells. The Axl protein was highly expressed in ccRCC cells deficient in functional von Hippel-Lindau (VHL) protein, a tumor suppressor gene often inactivated in ccRCC. VHL reconstituted cells expressed decreased levels of Axl protein, but not Axl mRNA, suggesting VHL to regulate Axl expression. Gas6-mediated activation of Axl in ccRCC cells resulted in Axl phosphorylation, receptor down-regulation, decreased cell-viability and migratory capacity. No effects of the Gas6/Axl system could be detected on invasion. Moreover, in ccRCC tumor tissues, Axl was phosphorylated and Gas6 gamma-carboxylated, suggesting these molecules to be active in vivo. SIGNIFICANCE: These results provide novel information regarding the complex function of the Gas6/Axl system in ccRCC.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Läkemedelskemi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medicinal Chemistry hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine hsv//eng
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Boström, Anna-KarinLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine(Swepub:lu)med-abm (author)
- Ljungberg, BörjeUmeå universitet,Urologi och andrologi(Swepub:umu)bolj0001 (author)
- Axelson, HåkanLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine(Swepub:lu)molm-hax (author)
- Dahlbäck, BjörnLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups(Swepub:lu)klke-bda (author)
- Klinisk kemi, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)
Related titles
- In:PloS one: Public Library of Science (PLoS)4:10, s. e7575-1932-6203
Internet link
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007575&type=printable
- https://portal.research.lu.se/files/4189901/1516316.pdfFULLTEXT
- http://www.ncbi.nlm.nih.gov/pubmed/19888345?dopt=AbstractFULLTEXT
- http://dx.doi.org/10.1371/journal.pone.0007575FULLTEXT
- https://mau.diva-portal.org/smash/get/diva2:1400916/FULLTEXT01.pdffulltext:postprint
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-33260
- https://doi.org/10.1371/journal.pone.0007575
- https://lup.lub.lu.se/record/1512262
- https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-4091
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