Metabolic syndrome and endometrial carcinoma

• The authors examined the association between the metabolic syndrome and risk of incident endometrial and fatal uterine corpus cancer within a large prospective cohort study. Approximately 290,000 women from Austria, Norway, and Sweden were enrolled during 1974-2005, with measurements of height, weight, systolic and diastolic blood pressure, and circulating levels of glucose, total cholesterol, and triglycerides. Relative risks were estimated using Cox proportional hazards regression. The metabolic syndrome was assessed as a composite z score, as the standardized sum of z scores for body mass index, blood pressure, glucose, cholesterol, and triglycerides. A total of 917 endometrial carcinomas and 129 fatal cancers were identified. Increased risks of incident endometrial carcinoma and fatal uterine corpus cancer were seen for the metabolic syndrome factors combined, as well as for individual factors (except for cholesterol). The relative risk of endometrial carcinoma for the metabolic syndrome was 1.37 (95% confidence interval: 1.28, 1.46) per 1-unit increment of z score. The positive associations between metabolic syndrome factors (both individually and combined) and endometrial carcinoma were confined to the heaviest women. The association between the metabolic syndrome and endometrial carcinoma risk seems to go beyond the risk conferred by obesity alone, particularly in women with a high body mass index.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Keyword

adult

blood glucose/analysis

breast neoplasms/epidemiology/etiology/prevention & control

colorectal neoplasms/epidemiology/etiology/prevention & control

developed countries

emigrants and immigrants

female

humans

incidence

insulin resistance

life style

male

metabolic syndrome X/complications

neoplasms/epidemiology/etiology/*prevention & control

obesity/complications

overweight/complications

prostatic neoplasms/epidemiology/etiology/prevention & control

risk factors

Sweden/epidemiology

world health

cohort studies

endometrial neoplasm

MEDICINE

MEDICIN

cohort studies

endometrial neoplasms

metabolic syndrome X

Publication and Content Type

ref (subject category)

art (subject category)