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Iron stores and HFE...
Iron stores and HFE genotypes are not related to increased risk of first-time myocardial infarction : a prospective nested case-referent study
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- Ekblom, Kim, 1970- (author)
- Umeå universitet,Klinisk kemi
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- Marklund, Stefan L (author)
- Umeå universitet,Klinisk kemi
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- Jansson, Jan-Håkan (author)
- Umeå universitet,Medicin
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning
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- Weinehall, Lars (author)
- Umeå universitet,Epidemiologi och global hälsa
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- Hultdin, Johan (author)
- Umeå universitet,Klinisk kemi
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- English.
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In: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 150:2, s. 169-172
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objectives: Our objectives were to study the relationship between iron stores, HFE genotypes and the risk for first-ever myocardial infarction. Methods: First-ever myocardial infarction cases (n=618) and double matched referents from the Northern Sweden Health and Disease Cohort Study were studied in a prospective nested case-referent setting. Plasma iron, total iron binding capacity, transferrin iron saturation and ferritin were analyzed, as well as several confounders. HFE C282Y and H63D genotypes were determined. Results: There was an inverse risk association for myocardial infarction in the highest quartiles of iron (OR 0.68; 95% CI 0.48-0.96) and transferrin iron saturation (OR 0.62; 95% CI 0.42-0.89) in men. This association, however, was lost after adjusting for C-reactive protein. Women homozygous for H63D had a higher risk for myocardial infarction. Conclusions: No risk association between high iron stores and first-ever myocardial infarction was found. The higher risk in female H63D homozygotes is probably not related to iron metabolism.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- myocardial infarction
- iron
- ferritin
- HFE
- prospective
- Cardiovascular medicine
- Kardiovaskulär medicin
- Epidemiology
- Epidemiologi
- Clinical Chemistry
- klinisk kemi
Publication and Content Type
- ref (subject category)
- art (subject category)
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