Retinal function in Bothnia dystrophy. An electrophysiological study.

Using prolonged dark adaptometry, standard dark adaptation (DA) and prolonged DA full-field electroretinograms (ERGs), we analysed the retinal function in patients with Bothnia dystrophy (BD), a variant of recessive retinitis punctata albescens (RPA). A compromised rod and cone function, a likely dysfunction of the Müller cells, and indications of disturbed neuronal function of the inner retina, were found. With prolonged DA, a gradual increase in retinal sensitivity to light and an improvement of the ERG components occurred. The findings indicate a prolonged synthesis of photopigments, retardation of the visual process in the retinal pigment epithelium (RPE), and a loss of retinal cells, probably starting at a relatively early age in BD.

Sandgren, Ola,1946-Umeå universitet,Oftalmiatrik(Swepub:umu)olsa0001 (author)
Golovleva, IrinaUmeå universitet,Institutionen för medicinsk biovetenskap(Swepub:umu)irgo0001 (author)
Wachtmeister, LillemorUmeå universitet,Oftalmiatrik(Swepub:umu)liwa0001 (author)
Umeå universitetOftalmiatrik (creator_code:org_t)

By the author/editor: Burstedt, Marie ...; Sandgren, Ola, 1 ...; Golovleva, Irina; Wachtmeister, Li ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Ophthalmology

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