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Central nervous sys...
Central nervous system and ophthalmic involvement in nephropathia epidemica (European type of haemorrhagic fever with renal syndrome)
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- Ahlm, Clas, 1956- (author)
- Umeå universitet,Infektionssjukdomar
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- Lindén, Christina (author)
- Umeå universitet,Oftalmiatrik
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- Linderholm, M (author)
- Umeå universitet,Infektionssjukdomar
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- Alexeyev, O A (author)
- Umeå universitet,Virologi
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Billheden, J (author)
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- Elgh, Fredrik, 1957- (author)
- Umeå universitet,Virologi,Fredrik Elgh
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Fagerlund, M (author)
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- Zetterlund, B (author)
- Umeå universitet,Klinisk neurofysiologi
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Settergren, B (author)
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(creator_code:org_t)
- 1998
- 1998
- English.
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In: Journal of Infection. - 0163-4453 .- 1532-2742. ; 36:2, s. 149-155
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Central nervous system (CNS) - related symptoms occur in haemorrhagic fever with renal syndrome (HFRS). To study the CNS and ophthalmic involvement in nephropathia epidemica (NE), the European type of HFRS, we included 26 patients in a prospective study. Most common CNS-related symptoms were headache (96%), insomnia (83%), vertigo (79%), nausea (79%), and vomiting (71%). Ophthalmic symptoms were reported by 82% of patients; 41% had photophobia and 50% had impaired vision. A transient loss of vision was recorded in one patient, who also had a generalized seizure. Minor white matter lesions were found in about half of the patients investigated with brain magnetic resonance imaging (MRI). Electroencephalography (EEG) showed severe alterations in only one patient, and slight and reversible patterns in another two patients. Neopterin, interleukin-6 and interferon-gamma levels in the cerebrospinal fluid (CSF) were elevated, which may indicate immune activation. However, we found no evidence of intrathecal NE virus replication. We conclude that CNS-related symptoms are common in NE, and transient ophthalmic involvement can be demonstrated in about half of the patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Keyword
- nephropathia epidemica
- Ophtalmiatrics
- Oftalmiatrik
- oftalmiatrik
- Ophtalmology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ahlm, Clas, 1956 ...
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Lindén, Christin ...
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Linderholm, M
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Alexeyev, O A
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Billheden, J
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Elgh, Fredrik, 1 ...
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show more...
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Fagerlund, M
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Zetterlund, B
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Settergren, B
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Ophthalmology
- Articles in the publication
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Journal of Infec ...
- By the university
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Umeå University
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Karolinska Institutet