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Diffusion tensor im...
Diffusion tensor imaging in sporadic and familial (D90A SOD1) forms of amyotrophic lateral sclerosis
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Stanton, Biba R (author)
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Shinhmar, Daisy (author)
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Turner, Martin R (author)
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Williams, Victoria C (author)
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Williams, Steven C R (author)
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Blain, Camilla R V (author)
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Giampietro, Vincent P (author)
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Catani, Marco (author)
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Leigh, P Nigel (author)
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- Andersen, Peter M (author)
- Umeå universitet,Neurologi
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- Simmons, Andrew (author)
- Karolinska Institutet
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(creator_code:org_t)
- American Medical Association, 2009
- 2009
- English.
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In: Archives of Neurology. - : American Medical Association. - 0003-9942 .- 1538-3687. ; 66:1, s. 109-115
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https://jamanetwork....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: The basis of heterogeneity in the clinical presentation and rate of progression of amyotrophic lateral sclerosis (ALS) is poorly understood. OBJECTIVES: To use diffusion tensor imaging as a measure of axonal pathologic features in vivo in ALS and to compare a homogeneous form of familial ALS (homozygous D90A SOD1 [superoxide dismutase 1]) with sporadic ALS. DESIGN: Cross-sectional diffusion tensor imaging study. SETTING: Tertiary referral neurology clinic. PATIENTS: Twenty patients with sporadic ALS, 6 patients with homozygous D90A SOD1 ALS, and 21 healthy control subjects. MAIN OUTCOME MEASURE: Fractional anisotropy in cerebral white matter. RESULTS: Patients with homozygous D90A SOD1 ALS showed less extensive pathologic white matter in motor and extramotor pathways compared with patients with sporadic ALS, despite similar disease severity assessed clinically using a standard functional rating scale. Fractional anisotropy correlated with clinical measures of severity and upper motor neuron involvement. CONCLUSION: In vivo diffusion tensor imaging measures demonstrate differences in white matter degeneration between sporadic ALS and a unique familial form of the disease, indicating that genotype influences the distribution of cerebral pathologic features in ALS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Stanton, Biba R
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Shinhmar, Daisy
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Turner, Martin R
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Williams, Victor ...
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Williams, Steven ...
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Blain, Camilla R ...
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show more...
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Giampietro, Vinc ...
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Catani, Marco
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Leigh, P Nigel
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Andersen, Peter ...
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Simmons, Andrew
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Archives of Neur ...
- By the university
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Umeå University
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Karolinska Institutet