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  • Gallo, Valentina (author)

Smoking and risk for amyotrophic lateral sclerosis : analysis of the EPIC cohort

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • New York :J. Wiley & Sons,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-34692
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-34692URI
  • https://doi.org/10.1002/ana.21653DOI
  • https://lup.lub.lu.se/record/1428123URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Objective: Cigarette smoking has been reported as "probable" risk factor for Amyotrophic Lateral Sclerosis (ALS), a poorly understood disease in terms of aetiology. The extensive longitudinal data of the European Prospective Investigation into Cancer and Nutrition (EPIC) were used to evaluate age-specific mortality rates from ALS and the role of cigarette smoking on the risk of dying from ALS. Methods: A total of 517,890 healthy subjects were included, resulting in 4,591,325 person-years. ALS cases were ascertained through death certificates. Cox hazard models were built to investigate the role of smoking on the risk of ALS, using packs/years and smoking duration to study dose-response. Results: A total of 118 subjects died from ALS, resulting in a crude mortality rate of 2.69 per 100,000/year. Current smokers at recruitment had an almost two-fold increased risk of dying from ALS compared to never smokers (HR = 1.89, 95% C.I. 1.14-3.14), while former smokers at the time of enrollment had a 50% increased risk (HR = 1.48, 95% C.I. 0.94-2.32). The number of years spent smoking increased the risk of ALS (p for trend = 0.002). Those who smoked more than 33 years had more than a two-fold increased risk of ALS compared with never smokers (HR = 2.16, 95% C.I. 1.33-3.53). Conversely, the number of years since quitting smoking was associated with a decreased risk of ALS compared with continuing smoking. Interpretation: These results strongly support the hypothesis of a role of cigarette smoking in aetiology of ALS. We hypothesize that this could occur through lipid peroxidation via formaldehyde exposure.

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  • Bueno-De-Mesquita, H Bas (author)
  • Vermeulen, Roel (author)
  • Andersen, Peter MUmeå universitet,Neurologi(Swepub:umu)pean0001 (author)
  • Kyrozis, Andreas (author)
  • Linseisen, Jakob (author)
  • Kaaks, Rudolph (author)
  • Allen, Naomi E (author)
  • Roddam, Andrew W (author)
  • Boshuizen, Hendriek C (author)
  • Peeters, Petra H (author)
  • Palli, Domenico (author)
  • Mattiello, Amalia (author)
  • Sieri, Sabina (author)
  • Tumino, Rosario (author)
  • Jiménez-Martín, Juan-Manuel (author)
  • Díaz, María José Tormo (author)
  • Suarez, Laudina Rodriguez (author)
  • Trichopoulou, Antonia (author)
  • Agudo, Antonio (author)
  • Arriola, Larraitz (author)
  • Barricante-Gurrea, Aurelio (author)
  • Bingham, Sheila (author)
  • Khaw, Kay-Tee (author)
  • Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)smi-jma (author)
  • Lindkvist, Björn (author)
  • Overvad, Kim (author)
  • Bach, Flemming W (author)
  • Tjønneland, Anne (author)
  • Olsen, Anja (author)
  • Bergmann, Manuela M (author)
  • Boeing, Heiner (author)
  • Clavel-Chapelon, Francoise (author)
  • Lund, Eiliv (author)
  • Hallmans, Göran,1947-Umeå universitet,Näringsforskning(Swepub:umu)goha0001 (author)
  • Middleton, Lefkos (author)
  • Vineis, Paolo (author)
  • Riboli, Elio (author)
  • Umeå universitetNeurologi (creator_code:org_t)

Related titles

  • In:Annals of NeurologyNew York : J. Wiley & Sons65:4, s. 378-3850364-51341531-8249

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