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Synthesis of 2-(2-A...
Synthesis of 2-(2-Aminopyrimidine)-2,2-difluoroethanols as Potential Bioisosters of Salicylidene Acylhydrazides
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- Dahlgren, Markus K (author)
- Umeå universitet,Kemiska institutionen
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- Öberg, Christopher T (author)
- Umeå universitet,Kemiska institutionen
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- Wallin, Erika A (author)
- Umeå universitet,Kemiska institutionen
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- Janson, Pär G (author)
- Umeå universitet,Kemiska institutionen
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- Elofsson, Mikael (author)
- Umeå universitet,Kemiska institutionen
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(creator_code:org_t)
- 2010-06-21
- 2010
- English.
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In: Molecules. - : MDPI AG. - 1431-5157 .- 1420-3049. ; 15:6, s. 4207-12
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Salicylidene acylhydrazides are inhibitors of type III secretion in several Gramnegative pathogens. To further develop the salicylidene acylhydrazides, scaffold hopping was applied to replace the core fragment of the compounds. The novel 2-(2-aminopyrimidine)-2,2-difluoroethanol scaffold was identified as a possible analog to thesalicylidene acylhydrazide core structure. The synthesis of a library of 2-(2-aminopyrimidine)-2,2-difluoro-ethanols is described in this paper.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- scaffold hopping
- Reformatsky reaction
- salicylidene acylhydrazide
- type III secretion
- Chemistry
- Kemi
Publication and Content Type
- ref (subject category)
- art (subject category)
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