Circulating levels of insulin-like growth factor-I and risk of ovarian cancer.

Toniolo, Paolo (author)

Micheli, Andrea (author)

Akhmedkhanov, Arslan (author)

Rinaldi, Sabina (author)

Muti, Paola (author)

Biessy, Carine (author)

Krogh, Vittorio (author)

Zeleniuch-Jacquotte, Anne (author)

Berrino, Franco (author)

Riboli, Elio (author)

Kaaks, Rudolf (author)

(creator_code:org_t)

2002-09-17
2002
English.
In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 101:6, s. 549-554

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

Insulin-like growth factor (IGF)-I, a mitogenic and anti-apoptotic peptide, has been implicated in the development of several cancers. We hypothesized that high circulating IGF-I concentrations may be associated with an increased risk of ovarian cancer. A case-control study was nested within 3 prospective cohorts in New York (USA), Umeå (Sweden) and Milan (Italy). One hundred thirty-two women with primary invasive epithelial ovarian cancer diagnosed at least 1 year after blood donation were case subjects. For each case, 2 control subjects were selected, matching the case subject on cohort, menopausal status, age and date of recruitment (n = 263). Only women who did not use exogenous hormones at blood donation were included in the study. There was no association between IGF-I concentrations and ovarian cancer risk in the study group as a whole. In analyses restricted to subjects who had developed ovarian cancer at a young age (<55), circulating IGF-I was directly and strongly associated with ovarian cancer risk (OR = 4.97; 95% CI = 1.22-20.2 for the top vs. the bottom IGF-I tertile after adjustment for parity, BMI categories and smoking). There was no significant association of IGF binding protein-3 with ovarian cancer risk. We found a strong direct relationship between circulating IGF-I levels and risk of developing ovarian cancer before age 55. Additional, larger studies of this association are needed to provide more precise estimates of effect.

By the author/editor: Lukanova, Anneka ...; Lundin, Eva; Toniolo, Paolo; Micheli, Andrea; Akhmedkhanov, Ar ...; Rinaldi, Sabina; show more...; Muti, Paola; Lenner, Per; Biessy, Carine; Krogh, Vittorio; Zeleniuch-Jacquo ...; Berrino, Franco; Hallmans, Göran; Riboli, Elio; Kaaks, Rudolf; show less...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.