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Oxazole-modified gl...
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Andersson, Ida E.,1982-Umeå universitet,Kemiska institutionen
(author)
Oxazole-modified glycopeptides that target arthritis-associated class II MHC Aq and DR4 proteins
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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RSC Publishing,2010
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-35270
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-35270URI
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https://doi.org/10.1039/c003640dDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:120868293URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The glycopeptide CII259-273, a fragment from type II collagen (CII), can induce tolerance in mice susceptible to collagen-induced arthritis (CIA), which is a validated disease model for rheumatoid arthritis (RA). Here, we describe the design and synthesis of a small series of modified CII259-273 glycopeptides with oxazole heterocycles replacing three potentially labile peptide bonds. These glycopeptidomimetics were evaluated for binding to murine CIA-associated A(q) and human RA-associated DR4 class II major histocompatibility complex (MHC) proteins. The oxazole modifications drastically reduced or completely abolished binding to A(q). Two of the glycopeptidomimetics were, however, well tolerated in binding to DR4 and they also induced strong responses by one or two DR4-restricted T-cell hybridomas. This work contributes to the development of an altered glycopeptide for inducing immunological tolerance in CIA, with the long-term goal of developing a therapeutic vaccine for treatment of RA.
Added entries (persons, corporate bodies, meetings, titles ...)
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Batsalova, TsvetelinaMedical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
(author)
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Dzhambazov, BalikMedical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
(author)
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Edvinsson, LottaUmeå universitet,Kemiska institutionen(Swepub:umu)loed0002
(author)
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Holmdahl, RikardKarolinska Institutet
(author)
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Kihlberg, Jan,1957-Umeå universitet,Kemiska institutionen(Swepub:umu)jaki0001
(author)
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Linusson, Anna,1970-Umeå universitet,Kemiska institutionen(Swepub:umu)analin99
(author)
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Umeå universitetKemiska institutionen
(creator_code:org_t)
Related titles
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In:Organic and biomolecular chemistry: RSC Publishing8:13, s. 2931-29401477-05201477-0539
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