SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:umu-35716"
 

Search: onr:"swepub:oai:DiVA.org:umu-35716" > Adenovirus 11p down...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Adenovirus 11p downregulates CD46 early in infection

Gustafsson, Dan J (author)
Umeå universitet,Virologi
Andersson, Emma K, 1978- (author)
Umeå universitet,Virologi
Hu, Yan-Ling (author)
Umeå universitet,Virologi
show more...
Marttila, Marko (author)
Umeå universitet,Virologi
Lindman, Kristina (author)
Umeå universitet,Virologi
Strand, Mårten (author)
Umeå universitet,Virologi
Wang, Li (author)
Umeå universitet,Virologi
Mei, Ya-Fang (author)
Umeå universitet,Virologi
show less...
 (creator_code:org_t)
Elsevier BV, 2010
2010
English.
In: Virology. - : Elsevier BV. - 0042-6822 .- 1096-0341. ; 405:2, s. 474-482
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Adenovirus 11 prototype (Ad11p), belonging to species B, uses CD46 as an attachment receptor. CD46, a complement regulatory molecule, is expressed on all human nucleated cells. We show here that Ad11p virions downregulate CD46 on the surface of K562 cells as early as 5min p.i. Specific binding to CD46 by the Ad11p fiber knob was required to mediate downregulation. The complement regulatory factors CD55 and CD59 were also reduced to a significant extent as a consequence of Ad11p binding to K562 cells. In contrast, binding of Ad7p did not result in downregulation of CD46 early in infection. Thus, the presumed interaction between Ad7p and CD46 did not have the same consequences as the Ad11p-CD46 interaction, the latter virus (Ad11p) being a promising gene therapy vector candidate. These findings may lead to a better understanding of the pathogenesis of species B adenovirus infections.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

Keyword

Virology
Virologi

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

  • Virology (Search for host publication in LIBRIS)

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Search outside SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view