Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:DiVA.org:umu-36102" > Circulating C-react...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Aleksandrova, Krasimira (author)

Circulating C-reactive protein concentrations and risks of colon and rectal cancer : a nested case-control study within the European Prospective Investigation into Cancer and Nutrition

Article/chapterEnglish2010

Publisher, publication year, extent ...

2010-07-15
Oxford University Press (OUP),2010
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:umu-36102
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-36102URI
https://doi.org/10.1093/aje/kwq135DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

The authors investigated associations between serum C-reactive protein (CRP) concentrations and colon and rectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (1992-2003) among 1,096 incident cases and 1,096 controls selected using risk-set sampling and matched on study center, age, sex, time of blood collection, fasting status, menopausal status, menstrual cycle phase, and hormone replacement therapy. In conditional logistic regression with adjustment for education, smoking, nutritional factors, body mass index, and waist circumference, CRP showed a significant nonlinear association with colon cancer risk but not rectal cancer risk. Multivariable-adjusted relative risks for CRP concentrations of > or = 3.0 mg/L versus <1.0 mg/L were 1.36 (95% confidence interval (CI): 1.00, 1.85; P-trend = 0.01) for colon cancer and 1.02 (95% CI: 0.67, 1.57; P-trend = 0.65) for rectal cancer. Colon cancer risk was significantly increased in men (relative risk = 1.74, 95% CI: 1.11, 2.73; P-trend = 0.01) but not in women (relative risk = 1.06, 95% CI: 0.67, 1.68; P-trend = 0.13). Additional adjustment for C-peptide, glycated hemoglobin, and high density lipoprotein cholesterol did not attenuate these results. These data provide evidence that elevated CRP concentrations are related to a higher risk of colon cancer but not rectal cancer, predominantly among men and independently of obesity, insulin resistance, and dyslipidemia.

Subject headings and genre

LANTBRUKSVETENSKAPER Veterinärmedicin Patobiologi hsv//swe
AGRICULTURAL SCIENCES Veterinary Science Pathobiology hsv//eng
colorectal neoplasms
C-reactive protein
hyperglycemia
hyperinsulinism
hyperlipidemias
inflammation
obesity
abdominal
Pathology
Patologi
Pathology
patologi

Added entries (persons, corporate bodies, meetings, titles ...)

Jenab, Mazda (author)
Boeing, Heiner (author)
Jansen, Eugene (author)
Bueno-de-Mesquita, H Bas (author)
Rinaldi, Sabina (author)
Riboli, Elio (author)
Overvad, Kim (author)
Dahm, Christina C (author)
Olsen, Anja (author)
Tjønneland, Anne (author)
Boutron-Ruault, Marie-Christine (author)
Clavel-Chapelon, Françoise (author)
Morois, Sophie (author)
Palli, Domenico (author)
Krogh, Vittorio (author)
Tumino, Rosario (author)
Vineis, Paolo (author)
Panico, Salvatore (author)
Kaaks, Rudolf (author)
Rohrmann, Sabine (author)
Trichopoulou, Antonia (author)
Lagiou, Pagona (author)
Trichopoulos, Dimitrios (author)
van Duijnhoven, Fränzel JB (author)
Leufkens, Anke M (author)
Peeters, Petra H (author)
Rodríguez, Laudina (author)
Bonet, Catalina (author)
Sánchez, María-José (author)
Dorronsoro, Miren (author)
Navarro, Carmen (author)
Barricarte, Aurelio (author)
Palmqvist, RichardUmeå universitet,Patologi(Swepub:umu)ripa0001 (author)
Hallmans, GöranUmeå universitet,Näringsforskning(Swepub:umu)goha0001 (author)
Khaw, Kay-Tee (author)
Wareham, Nicholas (author)
Allen, Naomi E (author)
Spencer, Elizabeth (author)
Romaguera, Dora (author)
Norat, Teresa (author)
Pischon, Tobias (author)
Umeå universitetPatologi (creator_code:org_t)

Related titles

In:American Journal of Epidemiology: Oxford University Press (OUP)172:4, s. 407-4180002-92621476-6256

Internet link

Find in a library

American Journal of Epidemiology (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Aleksandrova, Kr ...; Jenab, Mazda; Boeing, Heiner; Jansen, Eugene; Bueno-de-Mesquit ...; Rinaldi, Sabina; show more...; Riboli, Elio; Overvad, Kim; Dahm, Christina ...; Olsen, Anja; Tjønneland, Anne; Boutron-Ruault, ...; Clavel-Chapelon, ...; Morois, Sophie; Palli, Domenico; Krogh, Vittorio; Tumino, Rosario; Vineis, Paolo; Panico, Salvator ...; Kaaks, Rudolf; Rohrmann, Sabine; Trichopoulou, An ...; Lagiou, Pagona; Trichopoulos, Di ...; van Duijnhoven, ...; Leufkens, Anke M; Peeters, Petra H; Rodríguez, Laudi ...; Bonet, Catalina; Sánchez, María-J ...; Dorronsoro, Mire ...; Navarro, Carmen; Barricarte, Aure ...; Palmqvist, Richa ...; Hallmans, Göran; Khaw, Kay-Tee; Wareham, Nichola ...; Allen, Naomi E; Spencer, Elizabe ...; Romaguera, Dora; Norat, Teresa; Pischon, Tobias; show less...

About the subject

AGRICULTURAL SCIENCES: AGRICULTURAL SCI ...; and Veterinary Scien ...; and Pathobiology

Articles in the publication: American Journal ...

By the university: Umeå University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se