The impact of Haemophilus influenzae type b vaccination in Sweden

Garpenholt, ÖrjanDepartment of Clinical Microbiology, Divisions of Infectious Epidemiology, Örebro Medical Centre Hospital, Örebro (author)

The number of patients with meningitis and bacteremia due to Haemophilus influenzae was studied in Sweden over the period 1987-1994. Conjugated H. influenzae type b vaccines were introduced in Sweden in 1992, and all children born after December 31, 1992, were offered vaccination free of charge. A rapid decline of H. influenzae meningitis and bacteraemia was observed in the autumn of 1993, when the expected peak incidence failed to appear. In the prevaccination period 1987-1991, the average annual incidence (cases/100,000) was 34.4 in children aged 0-4 years. In 1994, the annual incidence fell to 3.5. No significant decline was observed in older children or adults. There was a 92% reduction in the number of meningitis cases and an 83% reduction in cases of bacteraemia. A similar decline was noted in 2 regions which followed different strategies for the introduction of the vaccination programme.

Silfverdal, Sven ArneThe Departments Immunology, Örebro Medical Centre Hospital, Örebro(Swepub:umu)svar0002 (author)
Hugosson, SvantePaediatrics, Örebro Medical Centre Hospital, Örebro (author)
Fredlund, HansDepartment of Clinical Microbiology, Divisions of Infectious Epidemiology, Örebro Medical Centre Hospital, Örebro (author)
Bodin, LennartOtorhinolaryngology, Örebro Medical Centre Hospital, Örebro (author)
Romanus, VictoriaSwedish Institute for Infectious Disease Control, Stockholm, Sweden (author)
Olcén, PerOccupational Medicine, Unit of Biostatistics and Epidemiology, Örebro Medical Centre Hospital, Örebro (author)
Department of Clinical Microbiology, Divisions of Infectious Epidemiology, Örebro Medical Centre Hospital, ÖrebroThe Departments Immunology, Örebro Medical Centre Hospital, Örebro (creator_code:org_t)

In:Scandinavian Journal of Infectious Diseases28:2, s. 165-1690036-55481651-1980

By the author/editor: Garpenholt, Örja ...; Silfverdal, Sven ...; Hugosson, Svante; Fredlund, Hans; Bodin, Lennart; Romanus, Victori ...; show more...; Olcén, Per; show less...

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