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Tissue plasminogen ...
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Lindholm, ÅsaUppsala universitet,Institutionen för kvinnors och barns hälsa
(author)
Tissue plasminogen activator and plasminogen activator inhibitor 1 in obese and lean patients with polycystic ovary syndrome
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2010-05-26
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Informa UK Limited,2010
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-36927
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-36927URI
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https://doi.org/10.3109/09513590.2010.487592DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-134161URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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OBJECTIVE: Disturbances in the fibrinolytic system are predictors of future cardiovascular events. The aim of this study was to compare plasminogen activator inhibitor 1 (PAI-1) activity and tissue plasminogen activator (tPA) mass concentration between patients with polycystic ovary syndrome (PCOS) and control subjects. DESIGN: One hundred thirty-five patients with PCOS (lean and obese) and 81 healthy controls were recruited for the study. Blood samples for PAI-1 activity and tPA mass were collected together with anthropometric measures. RESULTS: Obese patients with PCOS displayed increased tPA mass concentration in comparison with controls (p <0.05), and this finding was consistent regardless of whether patients displayed signs of hyperandrogenism or not. When hyperandrogenism was introduced as a prerequisite for the PCOS diagnosis, obese patients with PCOS displayed increased PAI-1 activity as well, p <0.05. Lean patients with PCOS did not differ in terms of PAI-1 activity or tPA mass concentration in comparison to controls. CONCLUSION: Obese women with PCOS have impaired fibrinolysis, in particular if they also display objective biochemical markers of hyperandrogenism.
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Bixo, MarieUmeå universitet,Obstetrik och gynekologi(Swepub:umu)mabi0001
(author)
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Eliasson, MatsUmeå universitet,Medicin(Swepub:umu)mael0021
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Hudecova, MiriamUppsala universitet,Institutionen för kvinnors och barns hälsa(Swepub:uu)mirhu986
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Arnadottir, RagnheidurUppsala universitet,Institutionen för kvinnors och barns hälsa(Swepub:uu)ragoa862
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Holte, JanUppsala universitet,Institutionen för kvinnors och barns hälsa
(author)
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Sundström Poromaa, IngerUppsala universitet,Institutionen för kvinnors och barns hälsa(Swepub:uu)inspo702
(author)
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Uppsala universitetInstitutionen för kvinnors och barns hälsa
(creator_code:org_t)
Related titles
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In:Gynecological Endocrinology: Informa UK Limited26:10, s. 743-7480951-35901473-0766
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