Tissue plasminogen activator and plasminogen activator inhibitor 1 in obese and lean patients with polycystic ovary syndrome

Lindholm, ÅsaUppsala universitet,Institutionen för kvinnors och barns hälsa (author)

OBJECTIVE: Disturbances in the fibrinolytic system are predictors of future cardiovascular events. The aim of this study was to compare plasminogen activator inhibitor 1 (PAI-1) activity and tissue plasminogen activator (tPA) mass concentration between patients with polycystic ovary syndrome (PCOS) and control subjects. DESIGN: One hundred thirty-five patients with PCOS (lean and obese) and 81 healthy controls were recruited for the study. Blood samples for PAI-1 activity and tPA mass were collected together with anthropometric measures. RESULTS: Obese patients with PCOS displayed increased tPA mass concentration in comparison with controls (p <0.05), and this finding was consistent regardless of whether patients displayed signs of hyperandrogenism or not. When hyperandrogenism was introduced as a prerequisite for the PCOS diagnosis, obese patients with PCOS displayed increased PAI-1 activity as well, p <0.05. Lean patients with PCOS did not differ in terms of PAI-1 activity or tPA mass concentration in comparison to controls. CONCLUSION: Obese women with PCOS have impaired fibrinolysis, in particular if they also display objective biochemical markers of hyperandrogenism.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
Polycystic ovary syndrome
PAI-1
tPA
obesity
free androgen index
Obstetrics and women's diseases
Obstetrik och kvinnosjukdomar
obstetrik och gynekologi
Obstetrics and Gynaecology

Bixo, MarieUmeå universitet,Obstetrik och gynekologi(Swepub:umu)mabi0001 (author)
Eliasson, MatsUmeå universitet,Medicin(Swepub:umu)mael0021 (author)
Hudecova, MiriamUppsala universitet,Institutionen för kvinnors och barns hälsa(Swepub:uu)mirhu986 (author)
Arnadottir, RagnheidurUppsala universitet,Institutionen för kvinnors och barns hälsa(Swepub:uu)ragoa862 (author)
Holte, JanUppsala universitet,Institutionen för kvinnors och barns hälsa (author)
Sundström Poromaa, IngerUppsala universitet,Institutionen för kvinnors och barns hälsa(Swepub:uu)inspo702 (author)
Uppsala universitetInstitutionen för kvinnors och barns hälsa (creator_code:org_t)

In:Gynecological Endocrinology: Informa UK Limited26:10, s. 743-7480951-35901473-0766

By the author/editor: Lindholm, Åsa; Bixo, Marie; Eliasson, Mats; Hudecova, Miriam; Arnadottir, Ragn ...; Holte, Jan; show more...; Sundström Poroma ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

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