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Combining fibre opt...
Combining fibre optic Raman spectroscopy and tactile resonance measurement for tissue characterization
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- Candefjord, Stefan (author)
- Luleå tekniska universitet,Signaler och system
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- Nyberg, Morgan (author)
- Luleå tekniska universitet,Signaler och system
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- Jalkanen, Ville, 1978- (author)
- Umeå universitet,Centrum för medicinsk teknik och fysik (CMTF),Institutionen för tillämpad fysik och elektronik,Umeå University. Department of Applied Physics and Electronics
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- Ramser, Kerstin (author)
- Dept. of Computer Science and Electrical Engineering, Luleå University of Technology
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- Lindahl, Olof (author)
- Dept. of Computer Science and Electrical Engineering, Luleå University of Technology
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(creator_code:org_t)
- 2010-11-15
- 2010
- English.
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In: Measurement science and technology. - : IOP Publishing Ltd. - 0957-0233 .- 1361-6501. ; 21:125801, s. 1-8
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Tissue characterization is fundamental for identification of pathological conditions. Raman spectroscopy (RS) and tactile resonance measurement (TRM) are two promising techniques that measure biochemical content and stiffness, respectively. They have potential to complement the golden standard-–histological analysis. By combining RS and TRM, complementary information about tissue content can be obtained and specific drawbacks can be avoided. The aim of this study was to develop a multivariate approach to compare RS and TRM information. The approach was evaluated on measurements at the same points on porcine abdominal tissue. The measurement points were divided into five groups by multivariate analysis of the RS data. A regression analysis was performed and receiver operating characteristic (ROC) curves were used to compare the RS and TRM data. TRM identified one group efficiently (area under ROC curve 0.99). The RS data showed that the proportion of saturated fat was high in this group. The regression analysis showed that stiffness was mainly determined by the amount of fat and its composition. We concluded that RS provided additional, important information for tissue identification that was not provided by TRM alone. The results are promising for development of a method combining RS and TRM for intraoperative tissue characterization.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk laboratorie- och mätteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Laboratory and Measurements Technologies (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Annan medicinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Other Medical Engineering (hsv//eng)
Keyword
- tissue characterization
- multivariate analysis
- Raman spectroscopy
- tactile resonance measurement
- biological tissues
- Medical engineering
- Medicinsk teknik
- Medical Engineering for Healthcare
- Centre - Centre for Biomedical Engineering and Physics (CMTF)
Publication and Content Type
- ref (subject category)
- art (subject category)
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