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Reactions between G...
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Andersson, HansUmeå universitet,Kemiska institutionen
(author)
Reactions between Grignard reagents and heterocyclic N-oxides : stereoselective synthesis of substituted pyridines, piperidines, and piperazines
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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2011
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Royal Society of Chemistry (RSC),2011
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-38054
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-38054URI
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https://doi.org/10.1039/c0ob00336kDOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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In this perspective we discuss the recent developments of stereoselective synthesis of substituted pyridines, piperidines, and piperazines from cheap and commercially readily available starting materials. Pyridine N-oxides and pyrazine N-oxides are reacted with alkyl, aryl, alkynyl and vinyl Grignard reagents to give a diverse set of heterocycles in high yields. Optically active substituted piperazines are obtained by an asymmetric reaction from pyrazine N-oxides using sparteine as chiral ligand. In addition, a stereoselective synthesis of dienal-oximes from the reaction between pyridine N-oxides and Grignard reagents is presented, which results in a useful intermediate for the synthesis of a diverse set of compounds.
Added entries (persons, corporate bodies, meetings, titles ...)
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Olsson, Roger
(author)
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Almqvist, FredrikUmeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR)(Swepub:umu)fral0001
(author)
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Umeå universitetKemiska institutionen
(creator_code:org_t)
Related titles
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In:Organic and biomolecular chemistry: Royal Society of Chemistry (RSC)9, s. 337-3461477-05201477-0539
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