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PTGS2 and IL6 genet...
PTGS2 and IL6 genetic variation and risk of breast and prostate cancer : results from the Breast and Prostate Cancer Cohort Consortium (BPC3)
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2009-12-04
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Oxford University Press (OUP),2010
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-38258
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-38258URI
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https://doi.org/10.1093/carcin/bgp307DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Genes involved in the inflammation pathway have been associated with cancer risk. Genetic variants in the interleukin-6 (IL6) and prostaglandin-endoperoxide synthase-2 (PTGS2, encoding for the COX-2 enzyme) genes, in particular, have been related to several cancer types, including breast and prostate cancers. We conducted a study within the Breast and Prostate Cancer Cohort Consortium to examine the association between IL6 and PTGS2 polymorphisms and breast and prostate cancer risk. Twenty-seven polymorphisms, selected by pairwise tagging, were genotyped on 6292 breast cancer cases and 8135 matched controls and 8008 prostate cancer cases and 8604 matched controls. The large sample sizes and comprehensive single nucleotide polymorphism tagging in this study gave us excellent power to detect modest effects for common variants. After adjustment for multiple testing, none of the associations examined remained statistically significant at P = 0.01. In analyses not adjusted for multiple testing, one IL6 polymorphism (rs6949149) was marginally associated with breast cancer risk (TT versus GG, odds ratios (OR): 1.32; 99% confidence intervals (CI): 1.00-1.74, P(trend) = 0.003) and two were marginally associated with prostate cancer risk (rs6969502-AA versus rs6969502-GG, OR: 0.87, 99% CI: 0.75-1.02; P(trend) = 0.002 and rs7805828-AA versus rs7805828-GG, OR: 1.11, 99% CI: 0.99-1.26; P(trend) = 0.007). An increase in breast cancer risk was observed for the PTGS2 polymorphism rs7550380 (TT versus GG, OR: 1.38, 99% CI: 1.04-1.83). No association was observed between PTGS2 polymorphisms and prostate cancer risk. In conclusion, common genetic variation in these two genes might play at best a limited role in breast and prostate cancers.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Kaaks, Rudolf
(author)
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Canzian, Federico
(author)
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Albanes, Demetrius
(author)
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Berndt, Sonja I
(author)
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Boeing, Heiner
(author)
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Buring, Julie
(author)
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Chanock, Stephen J
(author)
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Clavel-Chapelon, Francoise
(author)
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Feigelson, Heather Spencer
(author)
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Gaziano, John M
(author)
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Giovannucci, Edward
(author)
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Gonzalez, Carlos
(author)
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Haiman, Christopher A
(author)
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Hallmans, Göran,1947-Umeå universitet,Näringsforskning(Swepub:umu)goha0001
(author)
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Hankinson, Susan E
(author)
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Hayes, Richard B
(author)
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Henderson, Brian E
(author)
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Hoover, Robert N
(author)
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Hunter, David J
(author)
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Khaw, Kay-Tee
(author)
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Kolonel, Laurence N
(author)
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Kraft, Peter
(author)
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Ma, Jing
(author)
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Le Marchand, Loic
(author)
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Lund, Eiliv
(author)
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Peeters, Petra H M
(author)
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Stampfer, Meir
(author)
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Stram, Dan O
(author)
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Thomas, Gilles
(author)
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Thun, Michael J
(author)
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Tjonneland, Anne
(author)
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Trichopoulos, Dimitrios
(author)
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Tumino, Rosario
(author)
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Riboli, Elio
(author)
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Virtamo, Jarmo
(author)
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Weinstein, Stephanie J
(author)
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Yeager, Meredith
(author)
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Ziegler, Regina G
(author)
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Cox, David G
(author)
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Umeå universitetNäringsforskning
(creator_code:org_t)
Related titles
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In:Carcinogenesis: Oxford University Press (OUP)31:3, s. 455-4610143-33341460-2180
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Dossus, Laure
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Kaaks, Rudolf
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Canzian, Federic ...
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Albanes, Demetri ...
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Berndt, Sonja I
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Boeing, Heiner
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Buring, Julie
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Chanock, Stephen ...
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Clavel-Chapelon, ...
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Feigelson, Heath ...
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Gaziano, John M
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Giovannucci, Edw ...
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Gonzalez, Carlos
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Haiman, Christop ...
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Hallmans, Göran, ...
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Hankinson, Susan ...
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Hayes, Richard B
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Henderson, Brian ...
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Hoover, Robert N
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Hunter, David J
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Khaw, Kay-Tee
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Kolonel, Laurenc ...
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Kraft, Peter
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Ma, Jing
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Le Marchand, Loi ...
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Lund, Eiliv
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Peeters, Petra H ...
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Stampfer, Meir
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Stram, Dan O
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Thomas, Gilles
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Thun, Michael J
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Tjonneland, Anne
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Trichopoulos, Di ...
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Tumino, Rosario
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Riboli, Elio
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Virtamo, Jarmo
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Weinstein, Steph ...
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Yeager, Meredith
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Ziegler, Regina ...
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Cox, David G
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Carcinogenesis
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Umeå University