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The INSIG2 rs756660...
The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk
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Campa, Daniele (author)
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Hüsing, Anika (author)
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McKay, James D (author)
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Sinilnikova, Olga (author)
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Vogel, Ulla (author)
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Tjønneland, Anne (author)
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Overvad, Kim (author)
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Stegger, Jakob (author)
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Clavel-Chapelon, Françoise (author)
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Chabbert-Buffet, Nathalie (author)
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Fagherazzi, Guy (author)
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Trichopoulou, Antonia (author)
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Zylis, Dimosthenis (author)
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Oustoglou, Erifili (author)
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Rohrmann, Sabine (author)
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Teucher, Birgit (author)
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Fisher, Eva (author)
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Boeing, Heiner (author)
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Masala, Giovanna (author)
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Krogh, Vittorio (author)
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Sacerdote, Carlotta (author)
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Panico, Salvatore (author)
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Tumino, Rosario (author)
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Onland-Moret, N Charlotte (author)
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van Gils, Carla H (author)
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Bueno-de-Mesquita, H Bas (author)
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Lund, Eiliv (author)
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Chirlaque, María Dolores (author)
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Sala, Núria (author)
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Quirós, José Ramon (author)
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Ardanaz, Eva (author)
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Amiano, Pilar (author)
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Molina-Montes, Esther (author)
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- Hallmans, Göran, 1947- (author)
- Umeå universitet,Näringsforskning
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- Lenner, Per (author)
- Umeå universitet,Onkologi
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Travis, Ruth C (author)
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Key, Timothy J (author)
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Wareham, Nick (author)
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Khaw, Kay-Tee (author)
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Rinaldi, Sabina (author)
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Slimani, Nadia (author)
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Chajes, Veronique (author)
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Siddiq, Afshan (author)
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Riboli, Elio (author)
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Kaaks, Rudolf (author)
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Canzian, Federico (author)
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(creator_code:org_t)
- 2010-10-18
- 2010
- English.
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In: BMC Cancer. - : BioMed Central. - 1471-2407. ; 10, s. 563-
- Related links:
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https://bmccancer.bi...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- BACKGROUND: The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings. BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC).METHODS: we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk.RESULTS AND CONCLUSIONS: In this study we were not able to find any statistically significant association between this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast cancer overall and by subgroups of age, or menopausal status.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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BMC Cancer
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To the university's database
- By the author/editor
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Campa, Daniele
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Hüsing, Anika
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McKay, James D
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Sinilnikova, Olg ...
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Vogel, Ulla
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Tjønneland, Anne
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show more...
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Overvad, Kim
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Stegger, Jakob
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Clavel-Chapelon, ...
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Chabbert-Buffet, ...
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Fagherazzi, Guy
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Trichopoulou, An ...
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Zylis, Dimosthen ...
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Oustoglou, Erifi ...
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Rohrmann, Sabine
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Teucher, Birgit
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Fisher, Eva
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Boeing, Heiner
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Masala, Giovanna
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Krogh, Vittorio
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Sacerdote, Carlo ...
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Panico, Salvator ...
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Tumino, Rosario
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Onland-Moret, N ...
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van Gils, Carla ...
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Bueno-de-Mesquit ...
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Lund, Eiliv
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Chirlaque, María ...
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Sala, Núria
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Quirós, José Ram ...
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Ardanaz, Eva
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Amiano, Pilar
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Molina-Montes, E ...
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Hallmans, Göran, ...
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Lenner, Per
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Travis, Ruth C
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Key, Timothy J
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Wareham, Nick
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Khaw, Kay-Tee
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Rinaldi, Sabina
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Slimani, Nadia
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Chajes, Veroniqu ...
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Siddiq, Afshan
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Riboli, Elio
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Kaaks, Rudolf
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Canzian, Federic ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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BMC Cancer
- By the university
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Umeå University