onr:"swepub:oai:DiVA.org:umu-3836"
Search: onr:"swepub:oai:DiVA.org:umu-3836" > The spontaneous pol...
- 1 of 1
- Previous record
- Next record
- To hitlist
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02474naa a2200337 4500 | |
| 001 | oai:DiVA.org:umu-3836 | |
| 003 | SwePub | |
| 008 | 040330s2003 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-38362 URI |
| 024 | 7 | a https://doi.org/10.1016/S0014-5793(03)00057-72 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Wilczynska, Malgorzatau Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut0 (Swepub:umu)mawi0006 |
| 245 | 1 0 | a The spontaneous polymerization of plasminogen activator inhibitor type-2 and Z-antitrypsin are due to different molecular aberrations |
| 264 | 1 | c 2003 |
| 338 | a print2 rdacarrier | |
| 520 | a The wild-type form of plasminogen activator inhibitor type-2 (PAI-2) and the pathogenic Z-mutant of alpha(1)-antitrypsin (alpha(1)AT) are serpins that spontaneously polymerize by the loop-sheet mechanism. Compared to the consensus serpin sequence, both PAI-2 and Z-alpha(1)AT have deviations in the so-called breach region located at the top of the A beta-sheet. In the case of Z-alpha(1)AT, conformational perturbations caused by a single amino acid substitution result in polymerization in vivo and predisposes to disease. To test whether the polymerization of PAI-2 is due to aberrations in the breach region, we constructed substitution mutants of PAI-2 with conserved residues in this region. Analysis of the mutants revealed that deviations in the breach region modulate but are not the major cause of PAI-2 polymerization. Rather, PAI-2 exists in a highly polymerogenic conformation and does not require conformational rearrangements before polymerization can take place. | |
| 653 | a Serpin | |
| 653 | a Loop–sheet polymerization | |
| 653 | a Plasminogen activator inhibitor type-2 | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Lobov, Sergeiu Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut |
| 700 | 1 | a Ny, Toru Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut0 (Swepub:umu)tony0001 |
| 710 | 2 | a Umeå universitetb Institutionen för medicinsk kemi och biofysik4 org |
| 773 | 0 | t FEBS Lettersg 537:1-3, s. 11-16q 537:1-3<11-16x 0014-5793x 1873-3468 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-3836 |
| 856 | 4 8 | u https://doi.org/10.1016/S0014-5793(03)00057-7 |
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Wilczynska, Malg ...
- Lobov, Sergei
- Ny, Tor
- Articles in the publication
- FEBS Letters
- By the university
- Umeå University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
