The effect of cph-82 on the growth of human-lymphocytes in vitro: definition of cytobiological action

The effect of cph-82 on the growth of human-lymphocytes in vitro : definition of cytobiological action

Norberg, B (author): Blood Centre, University Hospital S-901 85 Umeå, Sweden

Sondell, K (author): Blood Centre, University Hospital S-901 85 Umeå, Sweden

Nordenson, I (author): Department of Clinical Genetics, University Hospital S-901 85 Umeå, Sweden

Holmgren, G (author): Department of Clinical Genetics, University Hospital S-901 85 Umeå, Sweden

(creator_code:org_t)

Oxford University Press (OUP), 1989
1989
English.
In: British Journal of Rheumatology. - : Oxford University Press (OUP). - 0263-7103 .- 1460-2172. ; 28:5, s. 418-421

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

A drug composed of two semisynthetic podophyltine derivatives, CPH 82, has recently been launched for the treatment of severe rheumatoid arthritis. The present in vitro study of PHA-stimulated human T-lymphocytes showed that CPH 82 arrested cell division in a metaphase-like configuration. The cell cycle effects of CPH 82 were indistinguishable from the cell cycle effects of the classical microtubule depolymerizers, Colcemid (a colchicine derivative) and podophyllotoxin. A CPH 82 concentration of 1 (µg/ml, which is close to therapeutic serum concentrations, had an almost maximal effect on cell division. It is suggested that at least part of the anti-inflammatory effect of CPH 82 is due to a colchicine-like activity on, for example, proliferating lymphocytes.

By the author/editor: Dahlqvist, Solbr ...; Norberg, B; Sondell, K; Nordenson, I; Holmgren, G

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Rheumatology and ...

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