Search: onr:"swepub:oai:DiVA.org:umu-39198" >
The effect of cph-8...
The effect of cph-82 on the growth of human-lymphocytes in vitro : definition of cytobiological action
-
- Dahlqvist, Solbritt Rantapää (author)
- Umeå universitet,Reumatologi
-
- Norberg, B (author)
- Blood Centre, University Hospital S-901 85 Umeå, Sweden
-
- Sondell, K (author)
- Blood Centre, University Hospital S-901 85 Umeå, Sweden
-
show more...
-
- Nordenson, I (author)
- Department of Clinical Genetics, University Hospital S-901 85 Umeå, Sweden
-
- Holmgren, G (author)
- Department of Clinical Genetics, University Hospital S-901 85 Umeå, Sweden
-
show less...
-
(creator_code:org_t)
- Oxford University Press (OUP), 1989
- 1989
- English.
-
In: British Journal of Rheumatology. - : Oxford University Press (OUP). - 0263-7103 .- 1460-2172. ; 28:5, s. 418-421
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- A drug composed of two semisynthetic podophyltine derivatives, CPH 82, has recently been launched for the treatment of severe rheumatoid arthritis. The present in vitro study of PHA-stimulated human T-lymphocytes showed that CPH 82 arrested cell division in a metaphase-like configuration. The cell cycle effects of CPH 82 were indistinguishable from the cell cycle effects of the classical microtubule depolymerizers, Colcemid (a colchicine derivative) and podophyllotoxin. A CPH 82 concentration of 1 (µg/ml, which is close to therapeutic serum concentrations, had an almost maximal effect on cell division. It is suggested that at least part of the anti-inflammatory effect of CPH 82 is due to a colchicine-like activity on, for example, proliferating lymphocytes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Podophylline derivative
- CPH 82
- Antimitotic effects
- Arrest
- Rheumatology
- Reumatologi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database