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Limited role of lip...
Limited role of lipopolysaccharide Lewis antigens in adherence of Helicobacter pylori to the human gastric epithelium
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- Mahdavi, Jafar (author)
- Umeå universitet,Oral mikrobiologi
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- Borén, Thomas (author)
- Umeå universitet,Oral mikrobiologi
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Vandenbroucke-Grauls, Christina (author)
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Appelmelk, Ben J (author)
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(creator_code:org_t)
- 2003
- 2003
- English.
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In: Infection and Immunity. - 0019-9567 .- 1098-5522. ; 71:5, s. 2876-2880
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In vitro and in vivo studies from various groups have suggested that Helicobacter pylori lipopolysaccharide (LPS) Lewis x (Lex) antigens mediate bacterial adhesion. We have now reevaluated this hypothesis by studying the adherence in situ of H. pylori strain 11637 and its corresponding Lex-negative rfbM mutant to human gastric mucosa from patients (n 22) with various gastric pathologies. Significant binding of the parent strain was observed in only 8 out of 22 sections; in four out of eight patients, the Lex-negative mutant bound less well. One of these four patients displayed no gastric abnormalities, and the other three showed dysplasia, metaplasia, and adenocarcinoma, respectively; hence, we are unable to define the circumstances under which LPS-mediated adhesion takes place. We conclude that H. pylori LPS plays a distinct but minor role in adhesion.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- ODONTOLOGY
- ODONTOLOGI
Publication and Content Type
- ref (subject category)
- art (subject category)
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