onr:"swepub:oai:DiVA.org:umu-4007"
Search: onr:"swepub:oai:DiVA.org:umu-4007" > Expression pattern ...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Liu, KuiUmeå universitet,Institutionen för medicinsk kemi och biofysik (author)
Expression pattern and functional studies of matrix degrading proteases and their inhibitors in the mouse corpus luteum
- Article/chapterEnglish2003
Publisher, publication year, extent ...
- 2003
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-4007
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-4007URI
- https://doi.org/10.1016/S0303-7207(03)00147-3DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- The formation of the corpus luteum (CL) is accompanied with angiogenesis and tissue remodeling and its regression involves tissue degradation. Matrix degrading proteases such as plasminogen activators (PAs) and matrix metalloproteinases (MMPs) are thought to play important roles in such controlled proteolytic processes. In this study, in situ hybridization has been used to examine the regulation and expression pattern of mRNAs coding for proteases and protease inhibitors belonging to the PA- and MMP-systems during the life cycle of the CL in an adult pseudopregnant mouse model. Of the nine proteases and five protease inhibitors that were studied, the majority were found to be temporally expressed during the formation and/or the regression of the CL. However, the mRNAs coding for urokinase type PA (uPA), membrane-type 1 MMP (MT1-MMP), and tissue inhibitor of metalloproteinases type-3 (TIMP-3) were constantly expressed in the mouse CL throughout its whole life span. To study the functional role of uPA in the CL, we analyzed luteal formation and function in uPA deficient mice. Our results revealed no significant difference in ovarian weight, serum progesterone levels, and blood vessel density in the functional CL between uPA deficient and wild type control mice. The temporal and spatial expression pattern of proteases and protease inhibitors during the CL life span suggests that members of the PA- and MMP-systems may play important roles in the angiogenesis and tissue remodeling processes during CL formation, as well as in the tissue degradation during luteal regression. However, the absence of reproductive phenotypes in mice lacking uPA and several other matrix degrading proteases indicates that there are redundancies among different matrix degrading proteases or that tissue remodeling in the ovary may involve other additional unique elements.
Subject headings and genre
- Ovary
- Corpus luteum
- Plasminogen activators
- Matrix metalloproteinase
Added entries (persons, corporate bodies, meetings, titles ...)
- Wahlberg, PatrikUmeå universitet,Institutionen för medicinsk kemi och biofysik (author)
- Hägglund, Anna-CarinUmeå universitet,Institutionen för medicinsk kemi och biofysik(Swepub:umu)anha0004 (author)
- Ny, TorUmeå universitet,Institutionen för medicinsk kemi och biofysik(Swepub:umu)tony0001 (author)
- Umeå universitetInstitutionen för medicinsk kemi och biofysik (creator_code:org_t)
Related titles
- In:Molecular and Cellular Endocrinology205:1-2, s. 131-1400303-72071872-8057
Internet link
Find in a library
- Molecular and Cellular Endocrinology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Liu, Kui
- Wahlberg, Patrik
- Hägglund, Anna-C ...
- Ny, Tor
- Articles in the publication
- Molecular and Ce ...
- By the university
- Umeå University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
