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Ovarian hormone eff...
Ovarian hormone effects on 5-hydroxytryptamine (2A) and 5-hydroxytryptamine (2C) receptor mRNA expression in the ventral hippocampus and frontal cortex of female rats.
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- Birzniece, Vita (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Obstetrik och gynekologi
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- Johansson, I-M (author)
- Umeå universitet,Obstetrik och gynekologi
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- Wang, MD (author)
- Umeå universitet,Obstetrik och gynekologi
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- Bäckström, T (author)
- Umeå universitet,Obstetrik och gynekologi
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Olsson, T (author)
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(creator_code:org_t)
- 2002
- 2002
- English.
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In: Neuroscience Letters. - 0304-3940 .- 1872-7972. ; 319:3, s. 157-161
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Alterations in female gonadal hormones are associated with anxiety and mood changes. The aim of the present study was to determine influences of chronic gonadal hormone supplementation on 5-HT(2A) and 5-HT(2C) receptor mRNA levels in the ventral hippocampus and the frontal cerebral cortex. Ovariectomized adult female Sprague-Dawley rats (n=37) received implantation of subcutaneous pellets containing different dosages of 17beta-estradiol alone or in combination with progesterone, or placebo pellets, for 2 weeks. Serotonin receptor mRNA levels were analyzed by in situ hybridization in the ventral hippocampus and 5-HT(2A) receptor mRNA also in the frontal cortex. Estradiol treatment in combination with low-dose progesterone increased 5-HT(2A) receptor mRNA by 43% in the CA2 region of the ventral hippocampus, while estradiol combined with high-dose progesterone increased the expression of this gene by 84% in ventral CA1. 5-HT(2A) mRNA expression in the frontal cortex was not influenced by hormone manipulation. 5-HT(2C) receptor gene expression was in the ventral hippocampus decreased in the CA2, ventral CA1 and the subiculum subregions by high-dose estradiol treatment (8-20% decreases). Effects on mood by gonadal hormones can be mediated, at least partly, through influences on 5-HT(2A) and 5-HT(2C) receptor expression.
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- ref (subject category)
- art (subject category)
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