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Effect of narrow-ba...
Effect of narrow-band ultraviolet B phototherapy on p63 and microRNA (miR-21 and miR-125b) expression in psoriatic epidermis
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- Gu, Xiaolian (author)
- Umeå universitet,Patologi
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- Nylander, Elisabet (author)
- Umeå universitet,Dermatologi och venereologi
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Coates, Philip J (author)
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- Nylander, Karin (author)
- Umeå universitet,Patologi
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(creator_code:org_t)
- Medical Journals Sweden AB, 2011
- 2011
- English.
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In: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 0001-5555 .- 1651-2057. ; 91:4, s. 392-397
- Related links:
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https://www.medicalj...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Subject headings
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- Psoriasis is an inflammatory skin disease in which dysregulation of p63, a member of the p53 family that is crucial for skin development and maintenance, has been demonstrated. Involvement of miR-203, miR-21 and miR-125b, small non-coding RNAs implicated in the regulation of p63 or p53, has been suggested in the patho-genesis of psoriasis. To elucidate the roles of p63 and p63-related microRNAs in psoriasis and to increase our understanding of the mechanisms of narrow-band ultraviolet B (NB-UVB) phototherapy, we studied the effects of NB-UVB treatment on the expression of these molecules. Skin biopsies from 12 psoriasis patients were collected before, during and after NB-UVB therapy. Real-time PCR and immunohistochemistry showed that p63 expression was not significantly affected, whereas NB-UVB phototherapy significantly decreased expression of miR-21 (p = 0.003) and increased miR-125b levels (p = 0.003). The results indicate that the unresolved p63 abnormality in treated epidermis may play a role in maintenance of this disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Keyword
- psoriasis; NB-UVB phototherapy; p63; microRNA
- MEDICINE
- MEDICIN
- odontologi
- Odontology
Publication and Content Type
- ref (subject category)
- art (subject category)
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