Hyperferritinemia is associated with low incidence of graft versus host disease, high relapse rate, and impaired survival in patients with blood disorders receiving allogeneic hematopoietic stem cell grafts.

Wahlin, AndersUmeå universitet,Onkologi,Department of Hematology, Cancer Centre, University Hospital, 90185 Umea, Sweden (author)

High pre-transplantation serum ferritin levels have been reported to be associated with impaired survival post-transplantation in patients with acute myeloid leukemia or myelodysplastic syndrome. We performed a retrospective study of 309 patients who underwent allogeneic hematopoietic stem cell transplantation at two transplantation centers. The aim was to determine the effect of pre-transplantation hyperferritinemia on survival, graft versus host disease, and relapse. In both univariate and multivariate analysis, elevated ferritin levels were significantly associated with shorter overall and relapse-free survival times and increased relapse rate, but lower risk of chronic graft versus host disease. Elevated ferritin levels were not associated with non-relapse mortality. We hypothesize that ferritin may exert an immunosuppressive effect, reducing graft versus host disease and graft versus leukemia effects, resulting in increased risk of relapse and impaired survival.

Lorenz, FryderykUmeå universitet,Onkologi,Hematology, Department of Radiation Sciences(Swepub:umu)frlo0008 (author)
Fredriksson, MarithaDepartment of Hematology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden (author)
Remberger, MatsKarolinska Institutet (author)
Wahlin, Björn EKarolinska Institutet (author)
Hägglund, HansDepartment of Hematology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden (author)
Umeå universitetOnkologi (creator_code:org_t)

In:Medical Oncology: Springer Science and Business Media LLC28:2, s. 552-5581357-05601559-131X

By the author/editor: Wahlin, Anders; Lorenz, Fryderyk; Fredriksson, Mar ...; Remberger, Mats; Wahlin, Björn E; Hägglund, Hans

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

By the university: Umeå University; Uppsala University; Karolinska Institutet

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.