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Anti-apoptotic role...
Anti-apoptotic role for C1 inhibitor in ischemia/reperfusion-induced myocardial cell injury.
- Article/chapterEnglish2006
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Elsevier BV,2006
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-41176
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-41176URI
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https://doi.org/10.1016/j.bbrc.2006.08.065DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Complement activation augments myocardial cell injury and apoptosis during ischemia/reperfusion (I/R), whereas complement system inhibition with C1 inhibitor (C1INH), a serine protease inhibitor, exerts markedly cardioprotective effects. Our recent data demonstrate that C1INH prevents vascular endothelial cell apoptosis and a "modified" form of the reactive center loop-cleaved, inactive C1INH (iC1INH) plays an anti-inflammatory role in endotoxin shock. The aim of this study was to determine whether C1INH protects against myocardial cell injury via an anti-apoptotic activity or anti-inflammatory effect. In a rat model of acute myocardial infarction (AMI) induced by I/R, administration of C1INH protected against cardiomyocytic apoptosis via normalization of ratio of the Bcl-2/Bax expression in the myocardial infarct area. C1INH improved parameters of cardiac function and hemodynamics and reduced myocardial infarct size (MIS). In addition, myocardial and blood myeloperoxidase (MPO) activity, a marker of neutrophil infiltration, was decreased by treatment of C1INH. In cultured H9c2 rat cardiomyocytic cells, C1INH blocked hypoxia/reoxygenation-induced apoptosis in the absence of sera associated with inhibition of cytochrome c translocation and suppression of caspase-3 activation. The proportion of Bcl-2/Bax expression induced by hypoxia/reoxygenation was reversed by C1INH. Importantly, iC1INH also revealed these similar effects, indicating that C1INH has a direct anti-apoptotic activity. Therefore, these studies support the hypothesis that C1INH, in addition to inhibition of activation of the complement and contact systems, improves outcome in I/R-mediated myocardial cell injury via an anti-apoptotic activity independent of serine protease inhibitory activity.
Added entries (persons, corporate bodies, meetings, titles ...)
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Lin, Guosheng
(author)
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Wu, Zhiwei
(author)
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Ceng, Bin
(author)
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Wu, Yanxia
(author)
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Liang, Gong
(author)
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Qin, Gangjian
(author)
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Li, Jinan
(author)
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Chiu, Isaac
(author)
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Liu, Dongxu
(author)
Related titles
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In:Biochemical and Biophysical Research Communications - BBRC: Elsevier BV349:2, s. 504-120006-291X1090-2104
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Fu, Jinrong
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Lin, Guosheng
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Wu, Zhiwei
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Ceng, Bin
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Wu, Yanxia
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Liang, Gong
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Qin, Gangjian
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Li, Jinan
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Chiu, Isaac
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Liu, Dongxu
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Biochemical and ...
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Umeå University