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Ebola virus infection inversely correlates with the overall expression levels of promyelocytic leukaemia (PML) protein in cultured cells
- Björndal, Asa Szekely (author)
-
- Szekely, Laszlo (author)
- Karolinska Institutet
-
- Elgh, Fredrik (author)
- Umeå universitet,Virologi
- (creator_code:org_t)
- Springer Science and Business Media LLC, 2003
- 2003
- English.
- In: BMC Microbiology. - : Springer Science and Business Media LLC. - 1471-2180. ; 3, s. 6-
- Journal article (peer-reviewed)
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- We have established a simple fixation and immunofluorescence staining procedure that allows specific co-detection and precise sub-cellular localization of the PML nuclear bodies and the Ebola virus encoded proteins NP, VP35 and VP40 in formaldehyde treated cells. Interferon-alpha treatment delays virus production in vitro. Intact PML bodies may play an anti-viral role in Ebola infected cells.
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