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  • Wiklund, Fredrik EKarolinska Institutet (author)

Macrophage inhibitory cytokine-1 (MIC-1/GDF15) : a new marker of all-cause mortality

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • 2010-10-21
  • Wiley,2010
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-42226
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42226URI
  • https://doi.org/10.1111/j.1474-9726.2010.00629.xDOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:121600984URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Macrophage inhibitory cytokine-1 (MIC-1/GDF15) is a member of the TGF-b superfamily, previously studied in cancer and inflammation. In addition to regulating body weight, MIC-1/GDF15 may be used to predict mortality and/or disease course in cancer, cardiovascular disease (CVD), chronic renal and heart failure, as well as pulmonary embolism. These data suggested that MIC-1/GDF15 may be a marker of all-cause mortality. To determine whether serum MIC-1/GDF15 estimation is a predictor of all-cause mortality, we examined a cohort of 876 male subjects aged 35-80 years, selected from the Swedish Population Registry, and followed them for overall mortality. Serum MIC-1/GDF15 levels were determined for all subjects from samples taken at study entry. A second (independent) cohort of 324 same-sex twins (69% female) from the Swedish Twin Registry was similarly examined. All the twins had telomere length measured and 183 had serum levels of interleukin 6 (IL-6) and C-reactive protein (CRP) available. Patients were followed for up to 14 years and had cause-specific and all-cause mortality determined. Serum MIC-1/GDF15 levels predicted mortality in the all-male cohort with an adjusted odds ratio (OR) of death of 3.38 (95%CI 1.38-8.26). This finding was validated in the twin cohort. Serum MIC-1/GDF15 remained an independent predictor of mortality when further adjusted for telomere length, IL-6 and CRP. Additionally, serum MIC-1/GDF15 levels were directly correlated with survival time independently of genetic background. Serum MIC-1/GDF15 is a novel predictor of all-cause mortality.

Subject headings and genre

  • MIC-1/GDF15
  • all-cause mortality
  • serum marker
  • cytokine
  • prospective observational cohort
  • environmental toxicity

Added entries (persons, corporate bodies, meetings, titles ...)

  • Bennet, Anna MKarolinska Institutet (author)
  • Magnusson, Patrik K EKarolinska Institutet (author)
  • Eriksson, Ulrika K (author)
  • Lindmark, FredrikUmeå universitet,Urologi och andrologi (author)
  • Wu, Liyun (author)
  • Yaghoutyfam, Nasreen (author)
  • Marquis, Christopher P (author)
  • Stattin, PärUmeå universitet,Urologi och andrologi(Swepub:umu)past0003 (author)
  • Pedersen, Nancy LKarolinska Institutet (author)
  • Adami, Hans-OlovKarolinska Institutet (author)
  • Grönberg, HenrikKarolinska Institutet (author)
  • Breit, Samuel N (author)
  • Brown, David A (author)
  • Karolinska InstitutetUrologi och andrologi (creator_code:org_t)

Related titles

  • In:Aging Cell: Wiley9:6, s. 1057-10641474-97181474-9726

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