Search: onr:"swepub:oai:DiVA.org:umu-42226" >
Macrophage inhibito...
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Wiklund, Fredrik EKarolinska Institutet
(author)
Macrophage inhibitory cytokine-1 (MIC-1/GDF15) : a new marker of all-cause mortality
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2010-10-21
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Wiley,2010
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-42226
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42226URI
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https://doi.org/10.1111/j.1474-9726.2010.00629.xDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:121600984URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Macrophage inhibitory cytokine-1 (MIC-1/GDF15) is a member of the TGF-b superfamily, previously studied in cancer and inflammation. In addition to regulating body weight, MIC-1/GDF15 may be used to predict mortality and/or disease course in cancer, cardiovascular disease (CVD), chronic renal and heart failure, as well as pulmonary embolism. These data suggested that MIC-1/GDF15 may be a marker of all-cause mortality. To determine whether serum MIC-1/GDF15 estimation is a predictor of all-cause mortality, we examined a cohort of 876 male subjects aged 35-80 years, selected from the Swedish Population Registry, and followed them for overall mortality. Serum MIC-1/GDF15 levels were determined for all subjects from samples taken at study entry. A second (independent) cohort of 324 same-sex twins (69% female) from the Swedish Twin Registry was similarly examined. All the twins had telomere length measured and 183 had serum levels of interleukin 6 (IL-6) and C-reactive protein (CRP) available. Patients were followed for up to 14 years and had cause-specific and all-cause mortality determined. Serum MIC-1/GDF15 levels predicted mortality in the all-male cohort with an adjusted odds ratio (OR) of death of 3.38 (95%CI 1.38-8.26). This finding was validated in the twin cohort. Serum MIC-1/GDF15 remained an independent predictor of mortality when further adjusted for telomere length, IL-6 and CRP. Additionally, serum MIC-1/GDF15 levels were directly correlated with survival time independently of genetic background. Serum MIC-1/GDF15 is a novel predictor of all-cause mortality.
Subject headings and genre
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MIC-1/GDF15
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all-cause mortality
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serum marker
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cytokine
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prospective observational cohort
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environmental toxicity
Added entries (persons, corporate bodies, meetings, titles ...)
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Bennet, Anna MKarolinska Institutet
(author)
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Magnusson, Patrik K EKarolinska Institutet
(author)
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Eriksson, Ulrika K
(author)
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Lindmark, FredrikUmeå universitet,Urologi och andrologi
(author)
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Wu, Liyun
(author)
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Yaghoutyfam, Nasreen
(author)
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Marquis, Christopher P
(author)
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Stattin, PärUmeå universitet,Urologi och andrologi(Swepub:umu)past0003
(author)
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Pedersen, Nancy LKarolinska Institutet
(author)
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Adami, Hans-OlovKarolinska Institutet
(author)
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Grönberg, HenrikKarolinska Institutet
(author)
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Breit, Samuel N
(author)
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Brown, David A
(author)
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Karolinska InstitutetUrologi och andrologi
(creator_code:org_t)
Related titles
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In:Aging Cell: Wiley9:6, s. 1057-10641474-97181474-9726
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Wiklund, Fredrik ...
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Bennet, Anna M
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Magnusson, Patri ...
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Eriksson, Ulrika ...
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Lindmark, Fredri ...
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Wu, Liyun
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Yaghoutyfam, Nas ...
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Marquis, Christo ...
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Stattin, Pär
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Pedersen, Nancy ...
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Adami, Hans-Olov
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Grönberg, Henrik
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Breit, Samuel N
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Brown, David A
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Aging Cell
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Umeå University
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Karolinska Institutet