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Genetic variability...
Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC)
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Campa, Daniele (author)
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Hüsing, Anika (author)
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Chang-Claude, Jenny (author)
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Dostal, Lucie (author)
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Boeing, Heiner (author)
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Kröger, Janine (author)
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Tjønneland, Anne (author)
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Roswall, Nina (author)
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Overvad, Kim (author)
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Dahm, Christina C (author)
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Rodríguez, Laudina (author)
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Sala, Núria (author)
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Pérez, Maria José Sánchez (author)
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Larrañaga, Nerea (author)
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Chirlaque, Maria-Dolores (author)
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Ardanaz, Eva (author)
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Khaw, Kay-Tee (author)
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Wareham, Nick (author)
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Allen, Naomi E (author)
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Travis, Ruth C (author)
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Trichopoulou, Antonia (author)
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Naska, Androniki (author)
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Bamia, Christina (author)
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Palli, Domenico (author)
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Sieri, Sabina (author)
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Tumino, Rosario (author)
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Sacerdote, Carlotta (author)
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van Kranen, Henk J (author)
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Bas Bueno-de-Mesquita, H (author)
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- Stattin, Pär (author)
- Umeå universitet,Urologi och andrologi
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- Johansson, Mattias (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin,International Agency for Research on Cancer, Lyon, France
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Chajes, Veronique (author)
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Rinaldi, Sabina (author)
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Romieu, Isabelle (author)
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Siddiq, Afshan (author)
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Norat, Teresa (author)
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Riboli, Elio (author)
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Kaaks, Rudolf (author)
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Canzian, Federico (author)
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(creator_code:org_t)
- Elsevier, 2011
- 2011
- English.
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In: European Journal of Cancer. - : Elsevier. - 0959-8049 .- 1879-0852. ; 47:3, s. 420-427
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- A western lifestyle, characterised by low rates of energy expenditure and a high-energy diet rich in animal protein, saturated fats and refined carbohydrates, is associated with high incidence of prostate cancer in men. A high-energy nutritional status results in insulin/IGF signalling in cells, which in turn stimulates synthesis of fatty acids. We investigated whether the genetic variability of the genes belonging to the fatty acid synthesis pathway is related to prostate cancer risk in 815 prostate cancer cases and 1266 controls from the European Prospective Investigation on Cancer (EPIC). Using a tagging approach and selecting 252 SNPs in 22 genes, we covered all the common genetic variation of this pathway. None of the SNPs reached statistical significance after adjusting for multiple comparisons. Common SNPs in the fatty acid synthase pathway are not major contributors to prostate cancer risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- Fatty acid synthase
- Prostate cancer
- Susceptibility to cancer
- Genetic polymorphisms
- Oncology
- Onkologi
- Oncology
- onkologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Campa, Daniele
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Hüsing, Anika
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Chang-Claude, Je ...
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Dostal, Lucie
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Boeing, Heiner
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Kröger, Janine
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show more...
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Tjønneland, Anne
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Roswall, Nina
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Overvad, Kim
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Dahm, Christina ...
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Rodríguez, Laudi ...
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Sala, Núria
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Pérez, Maria Jos ...
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Larrañaga, Nerea
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Chirlaque, Maria ...
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Ardanaz, Eva
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Khaw, Kay-Tee
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Wareham, Nick
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Allen, Naomi E
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Travis, Ruth C
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Trichopoulou, An ...
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Naska, Androniki
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Bamia, Christina
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Palli, Domenico
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Sieri, Sabina
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Tumino, Rosario
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Sacerdote, Carlo ...
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van Kranen, Henk ...
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Bas Bueno-de-Mes ...
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Stattin, Pär
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Johansson, Matti ...
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Chajes, Veroniqu ...
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Rinaldi, Sabina
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Romieu, Isabelle
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Siddiq, Afshan
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Norat, Teresa
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Riboli, Elio
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Kaaks, Rudolf
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Canzian, Federic ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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European Journal ...
- By the university
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Umeå University