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VKORC1-1639G>A, CYP...
VKORC1-1639G>A, CYP2C9, EPHX1691A>G genotype, body weight, and age are important predictors for warfarin maintenance doses in patients with mechanical heart valve prostheses in southwest China
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Gu, Qiang (author)
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Kong, Yan (author)
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- Schneede, Jörn (author)
- Umeå universitet,Klinisk kemi,Klinisk farmakologi
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Xiao, Ying-Bin (author)
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Chen, Lin (author)
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Zhong, Qian-Jin (author)
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Wang, Xue-Feng (author)
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Hao, Jia (author)
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Chen, Bai-Cheng (author)
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Chen, Jing-Jin (author)
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(creator_code:org_t)
- 2010-09-15
- 2010
- English.
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In: European Journal of Clinical Pharmacology. - : Springer Science and Business Media LLC. - 0031-6970 .- 1432-1041. ; 66:12, s. 1217-1227
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- There were great interindividual differences in warfarin maintenance dosage (ranging from 0.6 to 8.4 mg/day) among the 127 patients with mechanical heart valve prostheses. VKORC1-1639G>A, CYP2C9, EPHX1691A>G polymorphism, body weight, and age were found to affect the dose demands. Multiple linear regression models incorporating genetic polymorphisms of VKORC1, CYP2C9, EPHX1691A>G, and the nongenetic factors of age and body weight were developed, and explained up to 76.8% of the total variation (adjusted R (2) of 0.743) in warfarin maintenance doses in southwest Chinese patients with mechanical heart valve prostheses.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Keyword
- Gene polymorphism
- Warfarin therapy
- SNP
- CYP2C9
- VKORC1-1639G>A
- EPHX1691A>G
- Southwest Han Chinese patients
- Mechanical heart valve prostheses
- Clinical chemistry
- Klinisk kemi
- Clinical Chemistry
- klinisk kemi
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Gu, Qiang
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Kong, Yan
-
Schneede, Jörn
-
Xiao, Ying-Bin
-
Chen, Lin
-
Zhong, Qian-Jin
-
show more...
-
Wang, Xue-Feng
-
Hao, Jia
-
Chen, Bai-Cheng
-
Chen, Jing-Jin
-
show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
- Articles in the publication
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European Journal ...
- By the university
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Umeå University