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Endogenous substanc...
Endogenous substance P production in the Achilles tendon increases with loading in an in vivo model of tendinopathy : peptidergic elevation preceding tendinosis-like tissue changes
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- Backman, Ludvig (author)
- Umeå universitet,Anatomi,Idrottsmedicin
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- Andersson, Gustav (author)
- Umeå universitet,Anatomi
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- Wennstig, Gabriel (author)
- Umeå universitet,Anatomi
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- Forsgren, Sture (author)
- Umeå universitet,Anatomi
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- Danielson, Patrik (author)
- Umeå universitet,Anatomi
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(creator_code:org_t)
- International Society of Musculoskeletal and Neuronal Interactions, 2011
- 2011
- English.
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In: Journal of Musculoskeletal and Neuronal Interactions - JMNI. - : International Society of Musculoskeletal and Neuronal Interactions. - 1108-7161. ; 11:2, s. 133-140
- Related links:
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http://www.ismni.org...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Objectives: To quantify the intratendinous levels of substance P (SP) at different stages of overload in an established modelfor Achilles tendinopathy (rabbit). Also, to study the distribution of the SP-receptor, the NK-1R, and the source of SP, in thetendon. Methods: Animals were subjected to the overuse protocol for 1, 3 or 6 weeks. One additional group served as unexercisedcontrols. Immunoassay (EIA), immunohistochemistry (IHC), and in situ hybridisation (ISH) were performed.Results: EIA revealedincreased SP-levels in the Achilles tendon of the exercised limb in all the experimental groups as compared to in thecontrols (statistically significant; p=0.01). A similar trend in the unexercised Achilles tendon was observed but was not statisticallysignificant (p=0.14). IHC and in ISH illustrated reactions of both SP and NK-1R mainly in blood vessel walls, but the receptorwas also found on tenocytes.Conclusions: Achilles tendon SP-levels are elevated already after 1 week of loading. This showsthat increased SP-production precedes tendinosis, as tendinosis-like changes occur only after a minimum of 3 weeks of exercise,as shown in a recent study using this model. We propose that central neuronal mechanism may be involved as similar trends wereobserved in the contralateral Achilles tendon.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Neuropeptides
- Neurokinin-1 Receptor
- Animal Model
- Overuse Injuries
- Rabbit
Publication and Content Type
- ref (subject category)
- art (subject category)
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