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Helicobacter pylori...
Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation
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- Mahdavi, Jafar (author)
- Umeå universitet,Oral mikrobiologi,Department of Odontology/Oral Microbiology, Umeå University, Umeå, Sweden
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- Sondén, B (author)
- Umeå universitet,Oral mikrobiologi,Department of Odontology/Oral Microbiology, Umeå University, Umeå, Sweden
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- Hurtig, Marina (author)
- Umeå universitet,Oral mikrobiologi,Department of Odontology/Oral Microbiology, Umeå University, Umeå, Sweden
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- Olfat, Farzad O (author)
- Umeå universitet,Oral mikrobiologi,Department of Odontology/Oral Microbiology, Umeå University, Umeå, Sweden and The Swedish Institute for Infectious Disease Control, Solna, Sweden
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- Forsberg, Lina (author)
- Umeå universitet,Oral mikrobiologi,Department of Odontology/Oral Microbiology, Umeå University, Umeå, Sweden
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- Roche, Niamh (author)
- Lund University,Lunds universitet,Institutionen för laboratoriemedicin,Medicinska fakulteten,Department of Laboratory Medicine,Faculty of Medicine,Institute of Medical Biochemistry, Göteborg University, Göteborg, Sweden
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- Ångström, Jonas (author)
- Institute of Medical Biochemistry, Göteborg University, Göteborg, Sweden
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- Larsson, Thomas (author)
- Institute of Medical Biochemistry, Göteborg University, Göteborg, Sweden
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- Teneberg, Susann (author)
- Institute of Medical Biochemistry, Göteborg University, Göteborg, Sweden
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- Karlsson, Karl-Anders (author)
- Institute of Medical Biochemistry, Göteborg University, Göteborg, Sweden
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- Altraja, Siiri (author)
- Institute of Molecular and Cell Biology, Tartu University, Estonia
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- Wadström, Torkel (author)
- Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine,Department of Infectious Diseases and Medical Microbiology, Lund University, Lund, Sweden
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- Kersulyte, Dangeruta (author)
- Department of Molecular Microbiology, Washington University Medical School, St. Louis, USA
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- Berg, Douglas E (author)
- Department of Molecular Microbiology, Washington University Medical School, St. Louis, USA
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- Dubois, Andre (author)
- Laboratory of Gastrointestinal and Liver Studies, Department of Medicine, USUHS, Bethesda, USA
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- Petersson, Christoffer, 1973- (author)
- Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet
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- Magnusson, Karl-Eric, 1946- (author)
- Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet
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- Norberg, Thomas (author)
- Department of Chemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden
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- Lindh, Frank (author)
- IsoSep AB, Tullinge, Sweden
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- Lundskog, Bertil B (author)
- Umeå universitet,Institutionen för medicinsk biovetenskap,Department of Medical Biosciences/Clinical Cytology, Umeå University, Umeå, Sweden
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- Arnqvist, Anna (author)
- Umeå universitet,Oral mikrobiologi,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Odontology/Oral Microbiology, Umeå University, Umeå, Sweden and Department of Molecular Biology, Umeå University, Umeå, Sweden
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- Hammarström, Lennart (author)
- Karolinska Institutet,Center for Biotechnology, Karolinska Institute, Novum, Huddinge, Sweden
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- Borén, Thomas (author)
- Umeå universitet,Oral mikrobiologi,Department of Odontology/Oral Microbiology, Umeå University, Umeå, Sweden
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(creator_code:org_t)
- American Association for the Advancement of Science, 2002
- 2002
- English.
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In: Science. - : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 297:5581, s. 573-578
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Abstract
Subject headings
Close
- Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) was isolated with the "retagging" method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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Science
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To the university's database
- By the author/editor
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Mahdavi, Jafar
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Sondén, B
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Hurtig, Marina
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Olfat, Farzad O
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Forsberg, Lina
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Roche, Niamh
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show more...
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Ångström, Jonas
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Larsson, Thomas
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Teneberg, Susann
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Karlsson, Karl-A ...
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Altraja, Siiri
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Wadström, Torkel
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Kersulyte, Dange ...
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Berg, Douglas E
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Dubois, Andre
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Petersson, Chris ...
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Magnusson, Karl- ...
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Norberg, Thomas
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Lindh, Frank
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Lundskog, Bertil ...
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Arnqvist, Anna
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Hammarström, Len ...
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Borén, Thomas
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Medical Biotechn ...
- Articles in the publication
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Science
- By the university
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Umeå University
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Lund University
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Karolinska Institutet
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Linköping University