Search: onr:"swepub:oai:DiVA.org:umu-4345" >
A crucial role for ...
A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster
-
- Lorén, Christina (author)
- Umeå universitet,Umeå centrum för molekylär patogenes (UCMP)
-
- Englund, Camilla (author)
- Umeå universitet,Umeå centrum för molekylär patogenes (UCMP)
-
- Grabbe, Caroline (author)
- Umeå universitet,Umeå centrum för molekylär patogenes (UCMP)
-
show more...
-
- Hallberg, Bengt (author)
- Umeå universitet,Patologi
-
Hunter, Tony (author)
-
- Palmer, Ruth H (author)
- Umeå universitet,Umeå centrum för molekylär patogenes (UCMP)
-
show less...
-
(creator_code:org_t)
- 2003-07-04
- 2003
- English.
-
In: EMBO Reports. - : Nature Publishing Group. - 1469-221X .- 1469-3178. ; 4:8, s. 781-786
- Related links:
-
https://europepmc.or...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The Drosophila melanogaster gene Anaplastic lymphoma kinase (Alk) is homologous to mammalian Alk, which encodes a member of the Alk/Ltk family of receptor tyrosine kinases (RTKs). In humans, the t(2;5) translocation, which involves the ALK locus, produces an active form of ALK, which is the causative agent in non-Hodgkin's lymphoma. The physiological function of the Alk RTK, however, is unknown. In this paper, we describe loss-of-function mutants in the Drosophila Alk gene that cause a complete failure of the development of the gut. We propose that the main function of Drosophila Alk during early embryogenesis is in visceral mesoderm development.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database