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Dual association of...
Dual association of a TRKA polymorphism with schizophrenia
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Van Schijndel, Jessica E. (author)
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Van Zweeden, Martine (author)
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Van Loo, Karen M. J. (author)
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Djurovic, Srdjan (author)
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Andreassen, Ole A. (author)
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Hansen, Thomas (author)
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Werge, Thomas (author)
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Nyegaard, Mette (author)
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Meden Sørensen, Karina (author)
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Nordentoft, Merete (author)
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Mortensen, Preben B. (author)
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Mors, Ole (author)
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Børglum, Anders D. (author)
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Del-Favero, Jurgen (author)
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- Norrback, Karl-Fredrik (author)
- Umeå universitet,Psykiatri,University of Antwerp, Antwerp; Department of Psychiatry, Hospital of Sunderby, Luleå, Sweden
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- Adolfsson, Rolf (author)
- Umeå universitet,Psykiatri,Department of Psychiatry, Hospital of Sunderby, Luleå, Sweden
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De Hert, Marc (author)
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Claes, Stephan (author)
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Cichon, Sven (author)
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Rietschel, Marcella (author)
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Nöthen, Markus M. (author)
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Kallunki, Pekka (author)
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Pedersen, Jan T. (author)
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Martens, Gerard J. M. (author)
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2011
- 2011
- English.
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In: Psychiatric Genetics. - : Lippincott Williams & Wilkins. - 0955-8829 .- 1473-5873. ; 21:3, s. 125-131
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- OBJECTIVE: An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor.METHODS: We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia case-control groups.RESULT: Remarkably, although in five of the groups a higher frequency of the risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor.CONCLUSION: An intriguing possibility is that this dual character of the TRKA SNP is caused by its interaction with endophenotypic and/or epistatic factors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- case-control study
- meta-analysis
- neurotrophic tyrosine kinase receptor 1
- protective factor
- risk factor
- Psychiatry
- Psykiatri
Publication and Content Type
- ref (subject category)
- art (subject category)
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Van Schijndel, J ...
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Van Zweeden, Mar ...
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Van Loo, Karen M ...
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Djurovic, Srdjan
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Andreassen, Ole ...
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Hansen, Thomas
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show more...
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Werge, Thomas
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Nyegaard, Mette
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Meden Sørensen, ...
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Nordentoft, Mere ...
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Mortensen, Prebe ...
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Mors, Ole
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Børglum, Anders ...
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Del-Favero, Jurg ...
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Norrback, Karl-F ...
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Adolfsson, Rolf
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De Hert, Marc
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Claes, Stephan
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Cichon, Sven
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Rietschel, Marce ...
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Nöthen, Markus M ...
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Kallunki, Pekka
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Pedersen, Jan T.
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Martens, Gerard ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Psychiatric Gene ...
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Umeå University