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Dual association of...
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Van Schijndel, Jessica E.
(author)
Dual association of a TRKA polymorphism with schizophrenia
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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Lippincott Williams & Wilkins,2011
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-43908
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-43908URI
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https://doi.org/10.1097/YPG.0b013e3283437194DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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OBJECTIVE: An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor.METHODS: We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia case-control groups.RESULT: Remarkably, although in five of the groups a higher frequency of the risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor.CONCLUSION: An intriguing possibility is that this dual character of the TRKA SNP is caused by its interaction with endophenotypic and/or epistatic factors.
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Van Zweeden, Martine
(author)
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Van Loo, Karen M. J.
(author)
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Djurovic, Srdjan
(author)
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Andreassen, Ole A.
(author)
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Hansen, Thomas
(author)
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Werge, Thomas
(author)
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Nyegaard, Mette
(author)
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Meden Sørensen, Karina
(author)
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Nordentoft, Merete
(author)
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Mortensen, Preben B.
(author)
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Mors, Ole
(author)
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Børglum, Anders D.
(author)
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Del-Favero, Jurgen
(author)
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Norrback, Karl-FredrikUmeå universitet,Psykiatri,University of Antwerp, Antwerp; Department of Psychiatry, Hospital of Sunderby, Luleå, Sweden(Swepub:umu)kaknok96
(author)
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Adolfsson, RolfUmeå universitet,Psykiatri,Department of Psychiatry, Hospital of Sunderby, Luleå, Sweden(Swepub:umu)road0001
(author)
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De Hert, Marc
(author)
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Claes, Stephan
(author)
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Cichon, Sven
(author)
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Rietschel, Marcella
(author)
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Nöthen, Markus M.
(author)
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Kallunki, Pekka
(author)
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Pedersen, Jan T.
(author)
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Martens, Gerard J. M.
(author)
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Umeå universitetPsykiatri
(creator_code:org_t)
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In:Psychiatric Genetics: Lippincott Williams & Wilkins21:3, s. 125-1310955-88291473-5873
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Werge, Thomas
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Claes, Stephan
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