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  • Van Schijndel, Jessica E. (author)

Dual association of a TRKA polymorphism with schizophrenia

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • Lippincott Williams & Wilkins,2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-43908
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-43908URI
  • https://doi.org/10.1097/YPG.0b013e3283437194DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVE: An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor.METHODS: We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia case-control groups.RESULT: Remarkably, although in five of the groups a higher frequency of the risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor.CONCLUSION: An intriguing possibility is that this dual character of the TRKA SNP is caused by its interaction with endophenotypic and/or epistatic factors.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Van Zweeden, Martine (author)
  • Van Loo, Karen M. J. (author)
  • Djurovic, Srdjan (author)
  • Andreassen, Ole A. (author)
  • Hansen, Thomas (author)
  • Werge, Thomas (author)
  • Nyegaard, Mette (author)
  • Meden Sørensen, Karina (author)
  • Nordentoft, Merete (author)
  • Mortensen, Preben B. (author)
  • Mors, Ole (author)
  • Børglum, Anders D. (author)
  • Del-Favero, Jurgen (author)
  • Norrback, Karl-FredrikUmeå universitet,Psykiatri,University of Antwerp, Antwerp; Department of Psychiatry, Hospital of Sunderby, Luleå, Sweden(Swepub:umu)kaknok96 (author)
  • Adolfsson, RolfUmeå universitet,Psykiatri,Department of Psychiatry, Hospital of Sunderby, Luleå, Sweden(Swepub:umu)road0001 (author)
  • De Hert, Marc (author)
  • Claes, Stephan (author)
  • Cichon, Sven (author)
  • Rietschel, Marcella (author)
  • Nöthen, Markus M. (author)
  • Kallunki, Pekka (author)
  • Pedersen, Jan T. (author)
  • Martens, Gerard J. M. (author)
  • Umeå universitetPsykiatri (creator_code:org_t)

Related titles

  • In:Psychiatric Genetics: Lippincott Williams & Wilkins21:3, s. 125-1310955-88291473-5873

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